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Product Details
PA5-113723
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human C14orf21
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2884238
Product Specific Information
Immunogen sequence: GGTILESERA RPRGSQSSEA QKTPAQECKP ADFEVPETFL NRLQDLSSSF
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 85%; Human: 100%; Mouse: 83%; Rabbit: 92%; Rat: 83%
Target Information
The C14orf21 gene, also known as SLIRP (SRA stem-loop interacting RNA binding protein), is located on chromosome 14 and encodes a mitochondrial protein involved in RNA processing. SLIRP is crucial for the stabilization and regulation of mitochondrial-encoded RNAs, which play a vital role in mitochondrial gene expression and overall mitochondrial function. The SLIRP protein interacts with RNA stem-loop structures, particularly those involved in the steroid receptor RNA activator (SRA), thereby regulating gene expression by modulating the activity of nuclear receptors. Defects in SLIRP can lead to impaired mitochondrial function, resulting in various clinical manifestations, including mitochondrial myopathy and other disorders related to mitochondrial dysfunction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NOP9 nucleolar protein homolog; Nucleolar protein 9; pumilio domain-containing protein C14orf21
Gene Aliases: C14orf21; KIAA2021; NOP9
UniProt ID: (Human) Q86U38
Entrez Gene ID: (Human) 161424
Performance Guarantee
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