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Invitrogen
C1QBP Monoclonal Antibody (60.11)
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Product Details
MA5-33335
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Hamster,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
60.11
Immunogen
Recombinant-gC1q-R corresponding to mature gC1q-R (amino acids 74-282)
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
no preservative
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2815473
Product Specific Information
Product is supplied at 1 mL (100 µL/mL). This antibody is directed against epitopes situated within the NH2-terminal stretch of gC1q-R corresponding to residues 76-93. This antibody recognizes the putative C1q binding site and reacts with the mature form, but has poor or no reactivity with the truncated form, lacking residues 74- 95.
In ELISA applications, this antibody can be used as the capture or detection antibody.
Target Information
Replication Protein A (RPA) (also known as human single-stranded DNA binding protein, or HSSB) is involved in DNA replication, repair, and recombination. RPA from human cells is a stable heterotrimer of 70kDa, 32-34kDa, and 11-14kDa subunits (RPA70, RPA32, and RPA14 respectively). RPA is required for the SV40 large tumor antigen-catalyzed unwinding of SV40 DNA and stimulates DNA polymerase alpha and delta. RPA34 is phosphorylated at the G1/S boundary of the cell cycle or upon exposure of cells to DNA damage-inducing agents including ionizing and UV radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C1qBP; Complement component 1 Q subcomponent-binding protein, mitochondrial; complement component 1, q subcomponent binding protein; GC1q-R protein; Glycoprotein gC1qBP; RPA
Gene Aliases: C1qbp; Gc1qbp; gC1qR; Habp1
UniProt ID: (Rat) O35796
Entrez Gene ID: (Chinese hamster) 100754945, (Rat) 29681
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
mRNA processing
apoptotic process
immune response
complement activation, classical pathway
RNA splicing
phosphatidylinositol 3-kinase signaling
regulation of complement activation
negative regulation of interferon-gamma production
negative regulation of interleukin-12 production
negative regulation of MDA-5 signaling pathway
negative regulation of RIG-I signaling pathway
mature ribosome assembly
positive regulation of apoptotic process
innate immune response
positive regulation of cell adhesion
negative regulation of mRNA splicing, via spliceosome
negative regulation of defense response to virus
positive regulation of protein kinase B signaling
positive regulation of mitochondrial translation
positive regulation of neutrophil chemotaxis
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of trophoblast cell migration
positive regulation of dendritic cell chemotaxis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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