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C1orf31 Polyclonal Antibody

C1orf31 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

C1orf31 Antibody (24209-1-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA ) fixed HEK-293 cells using 24209-1-AP (C1orf31 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

C1orf31 Antibody in Immunoprecipitation (IP)

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Product Details

24209-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

C1orf31 Fusion Protein Ag21525 (47-125 aa encoded by BC116455)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAAPSMKER QVCWGARDEY WKCLDENLED ASQCKKLRSS FESSCPQQWI KYFDKRRDYL KFKEKFEAGQ FEPSETTAKS (47-125 aa encoded by BC116455)

Target Information

C1orf31, also known as COA6, is a conserved mitochondrial protein required for respiratory complex IV biogenesis. Recently study reported that C1orf31 is required for maintenance of cytochrome c oxidase (CcO) subunit levels, and has role in the Cu delivery pathway to CcO. Defects in C1orf31 is associated with mitochondrial respiratory chain disease (MRCD). (24549041).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

High Expression of COA6 Is Related to Unfavorable Prognosis and Enhanced Oxidative Phosphorylation in Lung Adenocarcinoma.

International journal of molecular sciences

Zhang M,Liao X,Ji G,Fan X,Wu Q

Thu Mar 16 00:00:00 UTC 2023

High Expression of COA6 Is Related to Unfavorable Prognosis and Enhanced Oxidative Phosphorylation in Lung Adenocarcinoma.

International journal of molecular sciences

Zhang M,Liao X,Ji G,Fan X,Wu Q

Thu Mar 16 00:00:00 UTC 2023

COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase.

Cell reports

Soma S,Morgada MN,Naik MT,Boulet A,Roesler AA,Dziuba N,Ghosh A,Yu Q,Lindahl PA,Ames JB,Leary SC,Vila AJ,Gohil VM

Tue Dec 17 00:00:00 UTC 2019

Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency.

Human molecular genetics

Ghosh A,Trivedi PP,Timbalia SA,Griffin AT,Rahn JJ,Chan SS,Gohil VM

Tue Jul 01 00:00:00 UTC 2014

Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency.

Human molecular genetics

Ghosh A,Trivedi PP,Timbalia SA,Griffin AT,Rahn JJ,Chan SS,Gohil VM

Tue Jul 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: ca031; Cytochrome c oxidase assembly factor 6 homolog

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Gene Aliases: 1810063B05Rik; AI447995; C1orf31; CEMCOX4; COA6

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UniProt ID: (Human) Q5JTJ3, (Mouse) Q8BGD8

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Entrez Gene ID: (Human) 388753, (Mouse) 67892

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Function(s)

cytochrome-c oxidase activity copper ion binding protein binding poly(A) RNA binding

Process(es)

respiratory chain complex IV assembly plasma membrane ATP synthesis coupled electron transport hydrogen ion transmembrane transport biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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C1orf31 Polyclonal Antibody

C1orf31 Antibody (24209-1-AP) in ICC/IF

Product Details

24209-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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