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Proteintech
C1orf51 Polyclonal Antibody
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Product Details
21098-1-AP
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C1orf51 Fusion Protein Ag15364 (1-385 aa encoded by BC027999)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDSPSSVSS YSSYSLSSSF PTSPVNSDFG FPSDSEREDK GAHGPRPDTV GQRGGSRPSP GPIRCRHRSK VSGNQHTPSH PKQRGSASPM AGSGAKRSRD GELETSLNTQ GCTTEGDLLF AQKCKELQGF IPPLTDLLNG LKMGRFERGL SSFQQSVAMD RIQRIVGVLQ KPQMGERYLG TLLQVEGMLK TWFPQIAAQK SSLGGGKHQL TKHFPSHHSD SAASSPASPM EKMDQTQLGH LALKPKQPWH LTQWPAMNLT WIHTTPICNP PLSSPGTISF SHGPLGTGTG IGVILFLQHG VQPFTHSAPT TPVPPTTASP VIPGEPMKLS GEGPRCYSLP VTLPSDWSYT LSPPSLPTLA RKMTIGHREQ QRSHPPVAAD AHLLNL (1-385 aa encoded by B C027999)
Target Information
Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ChIP-derived repressor of network oscillator; Chrono; Circadian-associated transcriptional repressor; Computationally highlighted repressor of the network oscillator
Gene Aliases: C1orf51; CHRONO; CIART; GM129
UniProt ID: (Human) Q8N365
Entrez Gene ID: (Human) 148523
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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