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Invitrogen
C1q Monoclonal Antibody (3R9/2)
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Product Details
MA1-83963
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3R9/2
Immunogen
Globular head domain of C1q, purified from human plasma.
Conjugate
Form
Liquid
Concentration
1.1 mg/mL
Purification
Protein A
Storage buffer
BBS, pH 8.4
Contains
< 0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2067385
Product Specific Information
A suggested positive control for immunohistochemical applications for this product is kidney tissue from patients with streptococcal glomerulonephritis. Strong staining was observed in the glomeruli and in some cases the peritubular capillary (potentially clinically significant).
Mouse anti human C1q antibody, clone 004-43.X (3R9/2), recognizes human complement component 1 q (C1q), a approximately 156 kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system.
Target Information
C1q is a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: complement C1q chain A; complement C1q chain B; Complement C1q subcomponent subunit A; Complement C1q subcomponent subunit B; Complement C1q subcomponent subunit C; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement component 1, q subcomponent, B chain; complement component 1, q subcomponent, beta polypeptide; complement component 1, q subcomponent, C chain; complement component 1, q subcomponent, gamma polypeptide; complement component C1q, A chain; complement component C1q, B chain; complement subcomponent C1q chain B
Gene Aliases: C1Q-C; C1QA; C1QB; C1QC; C1QG
UniProt ID: (Human) P02745, (Human) P02746, (Human) P02747
Entrez Gene ID: (Human) 712, (Human) 713, (Human) 714
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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