Proteintech

C1qA Polyclonal Antibody

FIGURE: 1 / 8

C1qA Antibody (11602-1-AP) in WB

Human spleen tissue were subjected to SDS PAGE followed by western blot with 11602-1-AP (C1QA antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

C1qA Antibody in Immunoprecipitation (IP)

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Product Details

11602-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 6 publications 6 publications

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

C1qA Fusion Protein Ag2141 (1-245 aa encoded by BC030153)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody is raised against C1qA which is the A-chain polypeptide of human complement subcomponent C1q.

Immunogen sequence: MEGPRGWLV LCVLAISLAS MVTEDLCRAP DGKKGEAGRP GRRGRPGLKG EQGEPGAPGI RTGIQGLKGD QGEPGPSGNP GKVGYPGPSG PLGARGIPGI KGTKGSPGNI KDQPRPAFSA IRRNPPMGGN VVIFDTVITN QEEPYQNHSG RFVCTVPGYY YFTFQVLSQW EICLSIVSSS RGQVRRSLGF CDTTNKGLFQ VVSGGMVLQL QQGDQVWVEK DPKKGHIYQG SEADSVFSGF LIFPSA (1-245 aa encoded by B C030153)

Target Information

C1q is a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Blocking Two-Pore Domain Potassium Channel TREK-1 Inhibits the Activation of A1-Like Reactive Astrocyte Through the NF-κB Signaling Pathway in a Rat Model of Major Depressive Disorder.

Neurochemical research

Cong T,Sun Y,Zhou Y,Wu H,Li L,Chu Z,Chen X,Li J,Zhao D,Wang Y,Liu Y,Yin S,Xiao Z

Thu Jun 01 00:00:00 UTC 2023

Blocking Two-Pore Domain Potassium Channel TREK-1 Inhibits the Activation of A1-Like Reactive Astrocyte Through the NF-κB Signaling Pathway in a Rat Model of Major Depressive Disorder.

Neurochemical research

Cong T,Sun Y,Zhou Y,Wu H,Li L,Chu Z,Chen X,Li J,Zhao D,Wang Y,Liu Y,Yin S,Xiao Z

Thu Jun 01 00:00:00 UTC 2023

TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.

Neuron

Gratuze M,Schlachetzki JCM,D'Oliveira Albanus R,Jain N,Novotny B,Brase L,Rodriguez L,Mansel C,Kipnis M,O'Brien S,Pasillas MP,Lee C,Manis M,Colonna M,Harari O,Glass CK,Ulrich JD,Holtzman DM

Wed Jan 18 00:00:00 UTC 2023

Dietary intake of α-ketoglutarate ameliorates α-synuclein pathology in mouse models of Parkinson's disease.

Cellular and molecular life sciences : CMLS

Zhang W,Ding L,Zhang M,Zheng S,Ma R,Gong J,Mao H,Xu H,Xu P,Zhang Y

Fri May 19 00:00:00 UTC 2023

Cellular heterogeneity and immune microenvironment revealed by single-cell transcriptome in venous malformation and cavernous venous malformation.

Journal of molecular and cellular cardiology

Li Y,Yang J,Huang Y,Ge S,Song X,Jia R,Wang Y

Sat Jan 01 00:00:00 UTC 2022

Role of uromodulin and complement activation in the progression of kidney disease.

Oncology letters

Shen F,Liu M,Pei F,Yu L,Yang X

Wed Dec 01 00:00:00 UTC 2021

C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1.

Scientific reports

Alberts A,Klingberg A,Wessig AK,Combes C,Witte T,Brand K,Pich A,Neumann K

Tue Apr 14 00:00:00 UTC 2020

Immune quiescence of the brain is set by astroglial connexin 43.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Boulay AC,Mazeraud A,Cisternino S,Saubaméa B,Mailly P,Jourdren L,Blugeon C,Mignon V,Smirnova M,Cavallo A,Ezan P,Avé P,Dingli F,Loew D,Vieira P,Chrétien F,Cohen-Salmon M

Wed Mar 11 00:00:00 UTC 2015

Immune quiescence of the brain is set by astroglial connexin 43.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Boulay AC,Mazeraud A,Cisternino S,Saubaméa B,Mailly P,Jourdren L,Blugeon C,Mignon V,Smirnova M,Cavallo A,Ezan P,Avé P,Dingli F,Loew D,Vieira P,Chrétien F,Cohen-Salmon M

Wed Mar 11 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: complement C1q chain A; Complement C1q subcomponent subunit A; complement component 1, q subcomponent, A chain; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain

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Gene Aliases: AI255395; C1q; C1QA

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UniProt ID: (Human) P02745, (Rat) P31720, (Mouse) P98086

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Entrez Gene ID: (Human) 712, (Rat) 298566, (Mouse) 12259

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Function(s)

serine-type endopeptidase activity protein binding molecular_function

Process(es)

complement activation, classical pathway biological_process innate immune response proteolysis complement activation cell-cell signaling response to iron ion immune system process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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C1qA Polyclonal Antibody

C1qA Antibody (11602-1-AP) in WB

Product Details

11602-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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