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Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria (PubMed:24231807, PubMed:26774479, PubMed:27099988). Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU (PubMed:24231807). Plays a central role in regulating the uniplex complex response to intracellular calcium signaling (PubMed:27099988). Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling (PubMed:27099988).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Essential MCU regulator, mitochondrial; single-pass membrane protein with aspartate-rich tail 1; Single-pass membrane protein with aspartate-rich tail 1, mitochondrial; UPF0466 protein C22orf32 homolog, mitochondrial; UPF0466 protein C22orf32, mitochondrial
Gene Aliases: 1500032L24Rik; C22orf32; DDDD; dJ186O1.1; EMRE; RGD1311310; SMDT1
UniProt ID: (Human) Q9H4I9, (Mouse) Q9DB10
Entrez Gene ID: (Human) 91689, (Rat) 315166, (Mouse) 69029
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