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Proteintech
C4 alpha chain/C4b/C4d Polyclonal Antibody
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Product Details
22233-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C4 alpha chain/C4b/C4d Fusion Protein Ag17583 (1017-1336 aa encoded by BC063289)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody raised against 1017-1336aa of human C4-A protein can recognize C4 precursor, C4 alpha chain, C4b, and C4d.
Immunogen sequence: YLAPTLAAS RYLDKTEQWS TLPPETKDHA VDLIQKGYMR IQQFRKADGS YAAWLSRDSS TWLTAFVLKV LSLAQEQVGG SPEKLQETSN WLLSQQQADG SFQDPCPVLD RSMQGGLVGN DETVALTAFV TIALHHGLAV FQDEGAEPLK QRVEASISKA NSFLGEIASA GLLGAHAAAI TAYALTLTKA PVDLLGVAHN NLMAMAQETG DNLYWGSVTG SQSNAVSPTQ APRNPSDPMP QAPALWIETT AYALLHLLLH EGKAEMADQA AAWLTRQGSF QGGFRSTQDT VIALDALSAY WIASHTTEER GLNVTLSSTG R (1017-1336 aa encoded by BC063289)
Target Information
This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acidic C4; Acidic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2; c4 complement; C4A anaphylatoxin; Complement C4-A; MHC class III region complement; Rodgers form of C4; sex-limited protein
Gene Aliases: C4; C4A; C4A2; C4A3; C4A4; C4A6; C4AD; C4S; CO4; CPAMD2; RG; Slp
UniProt ID: (Human) P0C0L4
Entrez Gene ID: (Human) 720, (Mouse) 625018
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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