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Proteintech
C4BPA Polyclonal Antibody
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Product Details
11819-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
C4BPA Fusion Protein Ag2387 (289-597 aa encoded by BC022312)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
C4BP is composed of two polypeptides (alpha and beta chains), which have molecular weights of 70 and 45 kDa, respectively. This polyclonal antibody is raised against the C4BP alpha chain (C4BPA).
Immunogen sequence: PSPPACEPN SCINLPDIPH ASWETYPRPT KEDVYVVGTV LRYRCHPGYK PTTDEPTTVI CQKNLRWTPY QGCEALCCPE PKLNNGEITQ HRKSRPANHC VYFYGDEISF SCHETSRFSA ICQGDGTWSP RTPSCGDICN FPPKIAHGHY KQSSSYSFFK EEIIYECDKG YILVGQAKLS CSYSHWSAPA PQCKALCRKP ELVNGRLSVD KDQYVEPENV TIQCDSGYGV VGPQSITCSG NRTWYPEVPK CEWETPEGCE QVLTGKRLMQ CLPNPEDVKM ALEVYKLSLE IEQLELQRDS ARQSTLDKEL (289-597 aa encoded by BC022312)
Target Information
There are 3 variants of Complement component 4 binding protein (C4bp), which is composed of alpha and beta chains. The predominant form is a 570 kDa complex of 7 alpha chains and 1 beta chain. The other complexes formed are a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. C4bp regulates the activation of the classical complement pathway. It is a cofactor to the C3b/C4b inactivator, crucial to the proteolytic cleavage of C4b and important in cleavage of C3b. C4bp also regulates the C4bC2a complex (C3 convertase), accelerating its degradation by dissociating the complement fragment C2a. Both the C4bp alpha and beta chains interact with anticoagulant protein S and C4bp alpha binds protein S. C4bp is expressed in the blood serum.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C4b-binding protein alpha chain; C4bp; Proline-rich protein; PRP; RP11-164O23.4
Gene Aliases: C4BP; C4BPA; PRP
UniProt ID: (Human) P04003
Entrez Gene ID: (Human) 722
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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