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Abnova
C4BPB Monoclonal Antibody (1G9)
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Product Details
H00000725-M01
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
1G9
Immunogen
C4BPB (AAH05378, 1 a.a. approximately 251 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MFFWCACCLM VAWRVSASDE HCPELPPVDN SIFVAKEVEG QILGTYVCIK GYHLVGKKTL FCNASKEWDN TTTECRLGHC PDPVLVNGEF SSSGPVNVSD KITFMCNDHY ILKGSNRSQC LEDHTWAPPF PICKSRDCDP PGNPVHGYFE GNNFTLGSTI SYYCEDRYYL VGVQEQQCVD GEWSSALPVC KLIQEAPKPE CEKALLAFQE SKNLCEAMEN FMQQLKESGM TMEELKYSLE LKKAELKAKL L
Target Information
Complement component 4-binding protein (C4BP) is a plasma glycoprotein that inhibits the classical pathway of complement activation, which is mediated through antibody targeting of foreign antigen. Structurally, C4BP is a disulfide linked, multimeric protein that is composed of seven alpha chains and one beta chain. C4BP functions as a cofactor for C3beta inactivator in the cleavage of C3beta, and accelerates the decay of C4betaC2alpha (C3 convertase) by acting as a cofactor in the cleavage of C4beta by factor I. Streptococcal strains that express Ig-binding cell surface molecules, which are members of the M protein family, can bind to overlapping C4beta binding sites in C4BP and therefore, interfere with the classical pathway of complement activation. Bacteria-bound C4BP may be an evolved mechanism that downregulates complement activation in the bacterial host microenvironment, thereby reducing the occurrences of bacterial opsonization and phagocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C4b-binding protein beta chain
Gene Aliases: C4BP; C4BPB
UniProt ID: (Human) P20851
Entrez Gene ID: (Human) 725
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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