Proteintech

CA1 Polyclonal Antibody

CA1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CA1 Antibody (13198-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 13198-2-AP (CA1 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

CA1 Antibody in Immunoprecipitation (IP)

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Product Details

13198-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 6 publications 6 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CA1 Fusion Protein Ag3932 (1-261 aa encoded by BC027890)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.44 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASPDWGYD DKNGPEQWSK LYPIANGNNQ SPVDIKTSET KHDTSLKPIS VSYNPATAKE IINVGHSFHV NFEDNDNRSV LKGGPFSDSY RLFQFHFHWG STNEHGSEHT VDGVKYSAEL HVAHWNSAKY SSLAEAASKA DGLAVIGVLM KVGEANPKLQ KVLDALQAIK TKGKRAPFTN FDPSTLLPSS LDFWTYPGSL THPPLYESVT WIICKESISV SSEQLAQFRS LLSNVEGDNA VPMQHNNRPT QPLKGRTVRA SF (1-261 aa encoded by BC027890)

Target Information

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Upregulation of carbonic anhydrase 1 beneficial for depressive disorder.

Acta neuropathologica communications

Cheng K,Wang Y,He Y,Tian Y,Li J,Chen C,Xu X,Wu Z,Yu H,Chen X,Wu Y,Song W,Dong Z,Xu H,Xie P

Mon Apr 03 00:00:00 UTC 2023

Upregulation of carbonic anhydrase 1 beneficial for depressive disorder.

Acta neuropathologica communications

Cheng K,Wang Y,He Y,Tian Y,Li J,Chen C,Xu X,Wu Z,Yu H,Chen X,Wu Y,Song W,Dong Z,Xu H,Xie P

Mon Apr 03 00:00:00 UTC 2023

Upregulation of carbonic anhydrase 1 beneficial for depressive disorder.

Acta neuropathologica communications

Cheng K,Wang Y,He Y,Tian Y,Li J,Chen C,Xu X,Wu Z,Yu H,Chen X,Wu Y,Song W,Dong Z,Xu H,Xie P

Mon Apr 03 00:00:00 UTC 2023

Upregulation of carbonic anhydrase 1 beneficial for depressive disorder.

Acta neuropathologica communications

Cheng K,Wang Y,He Y,Tian Y,Li J,Chen C,Xu X,Wu Z,Yu H,Chen X,Wu Y,Song W,Dong Z,Xu H,Xie P

Mon Apr 03 00:00:00 UTC 2023

RhoB affects colitis through modulating cell signaling and intestinal microbiome.

Microbiome

Yang J,Pei G,Sun X,Xiao Y,Miao C,Zhou L,Wang B,Yang L,Yu M,Zhang ZS,Keller ET,Yao Z,Wang Q

Fri Sep 16 00:00:00 UTC 2022

Carbonic anhydrase and soluble adenylate cyclase regulation of cystic fibrosis cellular phenotypes.

American journal of physiology. Lung cellular and molecular physiology

Boyne K,Corey DA,Zhao P,Lu B,Boron WF,Moss FJ,Kelley TJ

Tue Mar 01 00:00:00 UTC 2022

Oral administration of human carbonic anhydrase I suppresses colitis in a murine inflammatory bowel disease model.

Scientific reports

Tange K,Yagi S,Takeshita E,Abe M,Yamamoto Y,Tomida H,Kawamura T,Hanayama M,Matsuura B,Ikeda Y,Hiasa Y

Wed Oct 26 00:00:00 UTC 2022

Oral administration of human carbonic anhydrase I suppresses colitis in a murine inflammatory bowel disease model.

Scientific reports

Tange K,Yagi S,Takeshita E,Abe M,Yamamoto Y,Tomida H,Kawamura T,Hanayama M,Matsuura B,Ikeda Y,Hiasa Y

Wed Oct 26 00:00:00 UTC 2022

Oral administration of human carbonic anhydrase I suppresses colitis in a murine inflammatory bowel disease model.

Scientific reports

Tange K,Yagi S,Takeshita E,Abe M,Yamamoto Y,Tomida H,Kawamura T,Hanayama M,Matsuura B,Ikeda Y,Hiasa Y

Wed Oct 26 00:00:00 UTC 2022

Quantitative Proteomic Analysis of Mouse Sciatic Nerve Reveals Post-injury Upregulation of ADP-Dependent Glucokinase Promoting Macrophage Phagocytosis.

Frontiers in molecular neuroscience

Zhang K,Wang Q,Liang Y,Yan Y,Wang H,Cao X,Shan B,Zhang Y,Li A,Fang Y

Tue Dec 07 00:00:00 UTC 2021

Loss of interleukin-10 receptor disrupts intestinal epithelial cell proliferation and skews differentiation towards the goblet cell fate.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Jenkins BR,Blaseg NA,Grifka-Walk HM,Deuling B,Swain SD,Campbell EL,Walk ST,Kominsky DJ

Tue Jun 01 00:00:00 UTC 2021

Ginsenoside Rg1 attenuates mechanical stress-induced cardiac injury via calcium sensing receptor-related pathway.

Journal of ginseng research

Lu ML,Wang J,Sun Y,Li C,Sun TR,Hou XW,Wang HX

Mon Nov 01 00:00:00 UTC 2021

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.

Frontiers in pharmacology

Lu M,Leng B,He X,Zhang Z,Wang H,Tang F

Thu Oct 01 00:00:00 UTC 2020

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.

Frontiers in pharmacology

Lu M,Leng B,He X,Zhang Z,Wang H,Tang F

Thu Oct 01 00:00:00 UTC 2020

Calcium Sensing Receptor-Related Pathway Contributes to Cardiac Injury and the Mechanism of Astragaloside IV on Cardioprotection.

Frontiers in pharmacology

Lu M,Leng B,He X,Zhang Z,Wang H,Tang F

Thu Oct 01 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: CA I; CA-I; CA-I {ECO:0000250|UniProtKB:P00915}; ca1 {ECO:0000250|UniProtKB:P00915}; CAB; Carbonate dehydratase I; carbonate dehydratase I {ECO:0000250|UniProtKB:P00915}; Carbonic anhydrase 1; carbonic anhydrase 1 {ECO:0000250|UniProtKB:P00915}; Carbonic anhydrase B; Carbonic anhydrase I; carbonic anhydrase I {ECO:0000250|UniProtKB:P00915}; Cyanamide hydratase CA1; epididymis secretory protein Li 11

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Gene Aliases: AW555628; CA-I; CA1; CAB; Car-1; Car1; HEL-S-11

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UniProt ID: (Human) P00915, (Rat) B0BNN3, (Mouse) P13634

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Entrez Gene ID: (Human) 759, (Rat) 310218, (Mouse) 12346

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Function(s)

arylesterase activity carbonate dehydratase activity protein binding zinc ion binding hydro-lyase activity lyase activity metal ion binding

Process(es)

one-carbon metabolic process bicarbonate transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CA1 Polyclonal Antibody

CA1 Antibody (13198-2-AP) in IHC (P)

Product Details

13198-2-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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