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Cellular Location: Cell membrane, Single-pass type I membrane protein, extracellular space
Immunogen sequence: QRSSLGARYT GCRVIALRSV KNGAETRVDL LCTYLQPLSG PGLPIKQVFH ELSQQTHGIT RLGPYSLDKD SLYLNGYNEP GPDEPPTTPK PATTFLPPLS
CA 125 determinant is present on a high molecular weight, mucin like glycoprotein of high molecular weight. CA 125 has been found on frozen sections of amnion and derivatives of coelomic and mullerian epithelium, including pleura, pericardium and peritoneum. In adult tissues, epithelial cells of fallopian tube, endometrium and endocervix; pancreas, colon, gall bladder, stomach, kidney, apocrine sweat gland and mammary gland. It is also found in mesothelial cell lining of pleura, pericardium and peritoneum. It is found in ovarian tumors of serous, endometrioid or clear cell types and adenocarcinomas of mullerian type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CA-125; ca-ovarian; CA125 ovarian cancer antigen; FLJ14303; MUC-16; mucin 16, cell surface associated; Mucin-16; Ovarian cancer-related tumor marker CA125; Ovarian carcinoma antigen CA125
Gene Aliases: 1110008I14Rik; CA125; Gm1480; MUC16; RGD1308422
UniProt ID: (Human) Q8WXI7
Entrez Gene ID: (Human) 94025, (Rat) 315451, (Mouse) 73732
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