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Immunogen sequence: TTRLSMWDRP DDLIGRADVD KIIQEPPHKK GMEELKKLRH PTPTMLSIQK WQFSMSAIKE EQELMEEINE DEPVKAKKRK RDDNKDIDSE KEAAMEAEIK A; Positive Samples: HeLa, Jurkat, SW480; Cellular Location: Nucleus
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.
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Protein Aliases: co-activator of 150 kDa; MGC133200; TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD; TATA box-binding protein-associated factor 2S; Transcription elongation regulator 1; Transcription factor CA150
Gene Aliases: CA150; TAF2S; TCERG1; Urn1
UniProt ID: (Human) O14776
Entrez Gene ID: (Human) 10915
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