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Proteintech
CA9 Monoclonal Antibody (1G4G5)
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Product Details
66243-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rabbit
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
1G4G5
Immunogen
CA9 Fusion Protein Ag1540 (31-408 aa encoded by BC014950)
Conjugate
Form
Liquid
Concentration
1.36 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LLMPVHPQR LPRMQEDSPL GGGSSGEDDP LGEEDLPSEE DSPREEDPPG EEDLPGEEDL PGEEDLPEVK PKSEEEGSLK LEDLPTVEAP GDPQEPQNNA HRDKEGDDQS HWRYGGDPPW PRVSPACAGR FQSPVDIRPQ LAAFCPALRP LELLGFQLPP LPELRLRNNG HSVQLTLPPG LEMALGPGRE YRALQLHLHW GAAGRPGSEH TVEGHRFPAE IHVVHLSTAF ARVDEALGRP GGLAVLAAFL EEGPEENSAY EQLLSRLEEI AEEGSETQVP GLDISALLPS DFSRYFQYEG SLTTPPCAQG VIWTVFNQTV MLSAKQLHTL SDTLWGPGDS RLQLNFRATQ PLNGRVIEAS FPAGVDSSPR AAEPVQLNS (31-408 aa encoded by BC014950)
Target Information
Carbonic anhydrase (CA) is an enzyme that assists rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in all mammalian tissues. There are many genes that are inducible by hypoxia, via HIF-1 alpha. CA IX is one of the most inducible genes because of its stability and location within the membrane. Carbonic anhydrases have a widespread role in regulating pH in normal tissues, by regulating hydrogen ion (H+) flux. The pH is important in cell death under hypoxia, thus a blockade of CA IX results in increased cell death under hypoxia. Therefore, CA IX has become a reliable histochemical marker of hypoxia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CA-9; CA-IX; Carbonate dehydratase IX; Carbonic anhydrase 9; Carbonic anhydrase IX; carbonic dehydratase; Membrane antigen MN; Membrane antigen MN homolog; P54 / 58N; P54/58N; pMW1; RCC-associated antigen G250; RCC-associated protein G250; Renal cell carcinoma-associated antigen G250
Gene Aliases: CA9; CAIX; Car9; G250; MN; MN/CA9
UniProt ID: (Human) Q16790, (Mouse) Q8VHB5
Entrez Gene ID: (Human) 768, (Mouse) 230099
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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