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Product Details
12351-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CABYR Fusion Protein Ag3012 (3-379 aa encoded by BC011996)
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SSKPRLVVP YGLKTLLEGI SRAVLKTNPS NINQFAAAYF QELTMYRGNT TMDIKDLVKQ FHQIKVEKWS EGTTPQKKLE CLKEPGKTSV ESKVPTQMEK STDTDEDNVT RTEYSDKTTQ FPSVYAVPGT EQTEAVGGLS SKPATPKTTT PPSSPPPTAV SPEFAYVPAD PAQLAAQMLA MATSERGQPP PCSNMWTLYC LTDKNQQGHP SPPPAPGPFP QATLYLPNPK DPQFQQHPPK VTFPTYVMGD TKKTSAPPFI LVGSNVQEAQ GWKPLPGHAV VSQSDVLRYV AMQVPIAVPA DEKYQKHTLS PQNANPPSGQ DVPRPKSPVF LSVAFPVEDV AKKSSGSGDK CAPFGSYGIA GEVTVTTAHK RRKAETEN (3-379 aa encoded by BC011996)
Target Information
Spermatozoa gain fertilization capacitation and hyperactivation after residing in the uterus or oviduct. Calcium, cAMP and protein tyrosine phosphorylation are necessary for the molecular mechanisms that allow for this transformation. CABYR (Calcium-binding tyrosine phosphorylation-regulated protein), also known as Fibrousheathin-2 or Cancer/testis antigen 88, is a 493 amino acid protein that is expressed in sperm flagella and exhibits increased tyrosine phosphorylation during capacitation. There are six named isoforms of CABYR that are produced as a result of alternative slicing events. Specifically, isoform 1 is expressed in the testis, while isoform 3 and isoform 5 are expressed in pancreas, brain and various brain tumors. Isoforms 1, 2 and 6 most likely bind calcium, whereas isoforms 3, 4 and 5 probably do not bind calcium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2); Calcium-binding protein 86; Calcium-binding tyrosine phosphorylation-regulated protein; calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2); Cancer/testis antigen 88; CT88; fibrousheathin 2; Fibrousheathin II; Fibrousheathin-2; FSP-2; testis tissue sperm-binding protein Li 84P; Testis-specific calcium-binding protein CBP86
Gene Aliases: 1700016C01Rik; 4933421A18Rik; CABYR; CABYRa; CABYRc; CABYRc/d; CABYRe; CBP86; CT88; FSP-2; FSP2
UniProt ID: (Human) O75952, (Mouse) Q9D424
Entrez Gene ID: (Human) 26256, (Mouse) 71132
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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