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Product Details
OSC00271W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region of 2150-2210 of rat CACNA1A conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in mouse.
Specificity of this antibody: CACNA1A.
Target Information
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the n-repeats occur in the 3 UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the n-repeats which encode a polyglutamine tract. Expansion of the n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BI; brain calcium channel 1; Brain calcium channel I; brain class A; calcium channel alpha 1A; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide isoform 4; Calcium channel, L type, alpha-1 polypeptide, isoform 4; calcium channel, voltage-dependent, alpha 1A subunit; leaner; Rat brain class A; RBA-I; rocker; tottering; Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Voltage-gated calcium channel subunit alpha Cav2.1
Gene Aliases: alpha1A; APCA; BccA1; BI; Caca1a; Cach4; Cacn3; Cacna1a; Cacnl1a4; Cav2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352; rbA-1; rkr; SCA6; tg
UniProt ID: (Mouse) P97445, (Rat) P54282
Entrez Gene ID: (Mouse) 12286, (Rat) 25398
sulfur amino acid metabolic process
glucose metabolic process
transport
ion transport
calcium ion transport
positive regulation of cytosolic calcium ion concentration
gamma-aminobutyric acid signaling pathway
chemical synaptic transmission
neuron-neuron synaptic transmission
neuromuscular synaptic transmission
synapse assembly
adult walking behavior
cell death
gamma-aminobutyric acid secretion
regulation of acetylcholine secretion, neurotransmission
cell growth
calcium ion regulated exocytosis
regulation of calcium ion-dependent exocytosis
transmission of nerve impulse
sensory perception of pain
spinal cord motor neuron differentiation
cerebellum maturation
cerebellar molecular layer development
cerebellar Purkinje cell layer development
cerebellar Purkinje cell differentiation
vestibular nucleus development
central nervous system neuron differentiation
cellular chloride ion homeostasis
negative regulation of hormone biosynthetic process
regulation of ion transmembrane transport
synaptic transmission, glutamatergic
neurotransmitter metabolic process
regulation of membrane potential
thyroid hormone metabolic process
hormone metabolic process
receptor clustering
negative regulation of neuron apoptotic process
response to pain
behavioral response to pain
calcium ion-regulated exocytosis of neurotransmitter
dendrite morphogenesis
regulation of axonogenesis
neurological system process
musculoskeletal movement, spinal reflex action
neuromuscular process controlling balance
neuromuscular process
membrane depolarization
synaptic transmission, GABAergic
transmembrane transport
rhythmic synaptic transmission
calcium ion import
calcium ion transmembrane transport
membrane depolarization during action potential
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