Alomone Labs, LTD

CACNA1A (CaV2.1) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

ACC-001-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (IHC)

1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)PSSPERAPGREGPYGRE, corresponding to amino acid residues 865-881 of rat CACNA1A, Intracellular loop between domains II and III
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the n-repeats occur in the 3 UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the n-repeats which encode a polyglutamine tract. Expansion of the n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BI; brain calcium channel 1; Brain calcium channel I; brain class A; calcium channel alpha 1A; calcium channel, L type, alpha-1 polypeptide; Calcium channel, L type, alpha-1 polypeptide isoform 4; Calcium channel, L type, alpha-1 polypeptide, isoform 4; calcium channel, voltage-dependent, alpha 1A subunit; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit; fetal brain Ca2+ voltage-gated channel alpha1A pore-forming subunit; leaner; Rat brain class A; RBA-I; rocker; tottering; Voltage-dependent P/Q-type calcium channel subunit alpha-1A; Voltage-gated calcium channel subunit alpha Cav2.1

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Gene Aliases: alpha1A; APCA; BccA1; BI; Caca1a; CACH4; CACN3; CACNA1A; CACNL1A4; CAV2.1; Ccha1a; EA2; FHM; HPCA; la; MHP; MHP1; nmf352; rbA-1; rkr; SCA6; tg

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UniProt ID: (Human) O00555, (Mouse) P97445, (Rat) P54282

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Entrez Gene ID: (Human) 773, (Mouse) 12286, (Rat) 25398

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Function(s)
voltage-gated calcium channel activity calcium channel activity protein binding high voltage-gated calcium channel activity syntaxin binding metal ion binding DNA binding ion channel activity voltage-gated ion channel activity calmodulin binding
Process(es)
sulfur amino acid metabolic process glucose metabolic process positive regulation of cytosolic calcium ion concentration gamma-aminobutyric acid signaling pathway neuromuscular synaptic transmission synapse assembly adult walking behavior cell death gamma-aminobutyric acid secretion regulation of acetylcholine secretion, neurotransmission cell growth regulation of calcium ion-dependent exocytosis transmission of nerve impulse spinal cord motor neuron differentiation cerebellum maturation cerebellar molecular layer development cerebellar Purkinje cell differentiation vestibular nucleus development cellular chloride ion homeostasis negative regulation of hormone biosynthetic process regulation of ion transmembrane transport synaptic transmission, glutamatergic neurotransmitter metabolic process hormone metabolic process receptor clustering negative regulation of neuron apoptotic process behavioral response to pain calcium ion-regulated exocytosis of neurotransmitter dendrite morphogenesis regulation of axonogenesis regulation of insulin secretion musculoskeletal movement, spinal reflex action neuromuscular process controlling balance membrane depolarization rhythmic synaptic transmission calcium ion transmembrane transport membrane depolarization during action potential transport ion transport calcium ion transport chemical synaptic transmission neuron-neuron synaptic transmission calcium ion regulated exocytosis sensory perception of pain cerebellar Purkinje cell layer development central nervous system neuron differentiation regulation of membrane potential thyroid hormone metabolic process response to pain neurological system process neuromuscular process synaptic transmission, GABAergic transmembrane transport calcium ion import
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