Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Osenses
CACNA1H, CACNA1G Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Details
OSC00114G-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 400-450 of human CACNA1G conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen shares 95% identity with the corresponding sequences in rat and mouse.
Specificity of this antibody: CACNA1H and CACNA1G.
Target Information
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. There are 2 isoforms of CACNA1H and 14 isoforms if CACNA1G, produced by alternative splicing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: calcium channel alpha13.2 subunit; calcium channel, voltage-dependent, T type, alpha 1G subunit; calcium channel, voltage-dependent, T type, alpha 1H subunit; calcium channel, voltage-dependent, T type, alpha 1Hb subunit; Cav3.1c; Low-voltage-activated calcium channel alpha1 3.2 subunit; low-voltage-activated calcium channel alpha13.2 subunit; NBR13; T-type Cav3.2; voltage dependent t-type calcium channel alpha-1H subunit; voltage-dependent calcium channel alpha 1G subunit, isoform 11; voltage-dependent T-type calcium channel alpha 1G subunit; Voltage-dependent T-type calcium channel subunit alpha-1G; Voltage-dependent T-type calcium channel subunit alpha-1H; voltage-gated calcium channel alpha subunit Cav3.2; voltage-gated calcium channel alpha subunit CavT.2; Voltage-gated calcium channel subunit alpha Cav3.1; Voltage-gated calcium channel subunit alpha Cav3.2
Gene Aliases: [a]1G; a1G; alpha-1G; alpha13.2; Ca(V)T.1; CACNA1G; CACNA1H; CACNA1HB; Cav3.1; Cav3.1d; Cav3.2; ECA6; EIG6; KIAA1123; mKIAA1123; MNCb-1209; NBR13; SCA42
UniProt ID: (Human) O43497, (Human) O95180, (Rat) Q9EQ60
Entrez Gene ID: (Human) 8913, (Human) 8912, (Rat) 29717, (Mouse) 12291, (Rat) 114862, (Mouse) 58226
low voltage-gated calcium channel activity
voltage-gated calcium channel activity involved in AV node cell action potential
voltage-gated calcium channel activity involved SA node cell action potential
scaffold protein binding
metal ion binding
voltage-gated calcium channel activity
protein binding
ion channel activity
voltage-gated ion channel activity
calcium channel activity
chemical synaptic transmission
response to nickel cation
regulation of ion transmembrane transport
regulation of membrane potential
positive regulation of calcium ion-dependent exocytosis
regulation of atrial cardiac muscle cell membrane depolarization
calcium ion import
calcium ion transmembrane transport
membrane depolarization during action potential
SA node cell action potential
AV node cell action potential
SA node cell to atrial cardiac muscle cell signalling
AV node cell to bundle of His cell signaling
membrane depolarization during AV node cell action potential
membrane depolarization during SA node cell action potential
regulation of heart rate by cardiac conduction
transport
muscle contraction
muscle organ development
myoblast fusion
regulation of heart contraction
aldosterone biosynthetic process
cellular response to hormone stimulus
cortisol biosynthetic process
cellular response to potassium ion
positive regulation of acrosome reaction
calcium ion transport
sensory perception of pain
action potential
regulation of heart rate
positive regulation of cytosolic calcium ion concentration
artery smooth muscle contraction
regulation of calcium ion transport
calcium ion transport into cytosol
cellular response to dexamethasone stimulus
ion transport
ion transmembrane transport
transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support