Product References
Sarcolipin haploinsufficiency prevents dystrophic cardiomyopathy in mdx mice.
American journal of physiology. Heart and circulatory physiology
Mareedu S,Pachon R,Thilagavathi J,Fefelova N,Balakrishnan R,Niranjan N,Xie LH,Babu GJ
MA3-921 was used in Western Blotting to understand how sarcolipin deficiency in mice effects cardiac SERCA function.
Fri Jan 01 00:00:00 UTC 2021
Effects of Topical Gabapentin on Ocular Pain and Tear Secretion.
Frontiers in pharmacology
Cammalleri M,Amato R,Olivieri M,Pezzino S,Bagnoli P,Dal Monte M,Rusciano D
MA3-921 was used in Western Blot to conclude that GBT is endowed with analgesic, anti-inflammatory and secretagogue properties, all useful to treat neuropathic pain of the ocular surface, especially in case of DED.
Fri Jun 25 00:00:00 UTC 2021
Effects of Topical Gabapentin on Ocular Pain and Tear Secretion.
Frontiers in pharmacology
Cammalleri M,Amato R,Olivieri M,Pezzino S,Bagnoli P,Dal Monte M,Rusciano D
MA3-921 was used in Western Blot to conclude that GBT is endowed with analgesic, anti-inflammatory and secretagogue properties, all useful to treat neuropathic pain of the ocular surface, especially in case of DED.
Fri Jun 25 00:00:00 UTC 2021
Effects of Topical Gabapentin on Ocular Pain and Tear Secretion.
Frontiers in pharmacology
Cammalleri M,Amato R,Olivieri M,Pezzino S,Bagnoli P,Dal Monte M,Rusciano D
MA3-921 was used in Western Blot to conclude that GBT is endowed with analgesic, anti-inflammatory and secretagogue properties, all useful to treat neuropathic pain of the ocular surface, especially in case of DED.
Fri Jun 25 00:00:00 UTC 2021
Prognostic value of α2δ1 in hypopharyngeal carcinoma: A retrospective study.
Open medicine (Warsaw, Poland)
Liu Q,Dong Y,Yuan S,Yu M,Liu L,Zhang Q
MA3-921 was used in Immunohistochemistry to identify the role of voltage-dependent calcium channel subunit alpha-2/delta-1 (α2δ1) in the prognosis of hypopharyngeal squamous cell carcinoma.
Fri Oct 08 00:00:00 UTC 2021
MicroRNA-107 inhibits proliferation and invasion of laryngeal squamous cell carcinoma cells by targeting CACNA2D1 in vitro.
Anti-cancer drugs
Huang C,Wang Z,Zhang K,Dong Y,Zhang A,Lu C,Liu L
MA3-921 was used in Immunohistochemistry to study how microRNAs regulate the expression of the CACNA2D1 gene in laryngeal cancer cells.
Sun Mar 01 00:00:00 UTC 2020
MicroRNA-107 inhibits proliferation and invasion of laryngeal squamous cell carcinoma cells by targeting CACNA2D1 in vitro.
Anti-cancer drugs
Huang C,Wang Z,Zhang K,Dong Y,Zhang A,Lu C,Liu L
MA3-921 was used in Immunohistochemistry to study how microRNAs regulate the expression of the CACNA2D1 gene in laryngeal cancer cells.
Sun Mar 01 00:00:00 UTC 2020
A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions.
PLoS genetics
Coste de Bagneaux P,von Elsner L,Bierhals T,Campiglio M,Johannsen J,Obermair GJ,Hempel M,Flucher BE,Kutsche K
MA3-921 was used in Western Blotting to investigate the functional implications of a CACNB4 missense variant in siblings with severe neurological disorder.
Sun Mar 01 00:00:00 UTC 2020
A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions.
PLoS genetics
Coste de Bagneaux P,von Elsner L,Bierhals T,Campiglio M,Johannsen J,Obermair GJ,Hempel M,Flucher BE,Kutsche K
MA3-921 was used in Western Blotting to investigate the functional implications of a CACNB4 missense variant in siblings with severe neurological disorder.
Sun Mar 01 00:00:00 UTC 2020
α2δ1 may be a potential marker for cancer stem cell in laryngeal squamous cell carcinoma.
Cancer biomarkers : section A of Disease markers
Huang C,Li Y,Zhao W,Zhang A,Lu C,Wang Z,Liu L
MA3-921 was used in Flow cytometry/Cell sorting to examine the expression of aα2δ1+ in laryngeal cancer tissues and determine the effect of α2δ1 on the migratory ability and tumourigenicity of laryngeal cancer cells.
Tue Jun 11 00:00:00 UTC 2019
SK channel enhancers attenuate Ca2+-dependent arrhythmia in hypertrophic hearts by regulating mito-ROS-dependent oxidation and activity of RyR.
Cardiovascular research
Kim TY,Terentyeva R,Roder KH,Li W,Liu M,Greener I,Hamilton S,Polina I,Murphy KR,Clements RT,Dudley SC,Koren G,Choi BR,Terentyev D
MA3921 was used in western blot to ask if SK channels in the mitochondria inner membrane play an important role in regulating mitochondrial function in chronic cardiac diseases
Wed Mar 01 00:00:00 UTC 2017
Cannabinoid signalling inhibits sarcoplasmic Ca2+ release and regulates excitation-contraction coupling in mammalian skeletal muscle.
The Journal of physiology
Oláh T,Bodnár D,Tóth A,Vincze J,Fodor J,Reischl B,Kovács A,Ruzsnavszky O,Dienes B,Szentesi P,Friedrich O,Csernoch L
MA3921 was used in western blot to examine the effects of marijuana on CB1R activation in skeletal muscle
Thu Dec 15 00:00:00 UTC 2016
Fluorescence Resonance Energy Transfer-based Structural Analysis of the Dihydropyridine Receptor α1S Subunit Reveals Conformational Differences Induced by Binding of the β1a Subunit.
The Journal of biological chemistry
Mahalingam M,Perez CF,Fessenden JD
MA3-921 was used in immunocytochemistry to analyze the dihydropyridine receptor alpha-1S subunit to reveal conformational differences induced by binding of the beta-1a subnit discovered by fluorescence resonance energy transfer-based structural analysis
Fri Jun 24 00:00:00 UTC 2016
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.
Nature communications
Sharma P,Abbasi C,Lazic S,Teng ACT,Wang D,Dubois N,Ignatchenko V,Wong V,Liu J,Araki T,Tiburcy M,Ackerley C,Zimmermann WH,Hamilton R,Sun Y,Liu PP,Keller G,Stagljar I,Scott IC,Kislinger T,Gramolini AO
MA3-921 was used in Western Blotting to identify Tmem65 as a previously uncharacterised cell-surface-associated protein with cardiac-enriched expression, and analyse its function.
Fri Sep 25 00:00:00 UTC 2015
Amino acid residues 489-503 of dihydropyridine receptor (DHPR) β1a subunit are critical for structural communication between the skeletal muscle DHPR complex and type 1 ryanodine receptor.
The Journal of biological chemistry
Eltit JM,Franzini-Armstrong C,Perez CF
MA3-921 was used in immunocytochemistry to determine the role of the C-terminal end of the beta1a subunit in the functional and structural communication between the DHPR and the Ca(2+) release channel (RyR1)
Fri Dec 26 00:00:00 UTC 2014
Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity.
PloS one
Groenke S,Larson ED,Alber S,Zhang R,Lamp ST,Ren X,Nakano H,Jordan MC,Karagueuzian HS,Roos KP,Nakano A,Proenza C,Philipson KD,Goldhaber JI
MA3-921 was used in western blot to study the elimination of sinoatrial node pacemaker activity by the complete atrial-specific ablation of NCX1
Tue Aug 05 00:00:00 UTC 2014
Tail-anchored membrane protein SLMAP is a novel regulator of cardiac function at the sarcoplasmic reticulum.
American journal of physiology. Heart and circulatory physiology
Nader M,Westendorp B,Hawari O,Salih M,Stewart AF,Leenen FH,Tuana BS
MA3-921 was used in western blot to study the modulation of cardiac function by SLAMPs using a murine transgenic model
Thu Mar 01 00:00:00 UTC 2012
Functional expression of transgenic 1sDHPR channels in adult mammalian skeletal muscle fibres.
The Journal of physiology
DiFranco M,Tran P,Quiñonez M,Vergara JL
MA3-921 was used in western blot to investigate the effect of alpha1sDHPR overexpression on calcium signaling in muscle fibers
Tue Mar 15 00:00:00 UTC 2011
Loss of the AE3 anion exchanger in a hypertrophic cardiomyopathy model causes rapid decompensation and heart failure.
Journal of molecular and cellular cardiology
Al Moamen NJ,Prasad V,Bodi I,Miller ML,Neiman ML,Lasko VM,Alper SL,Wieczorek DF,Lorenz JN,Shull GE
MA3-921 was used in western blot to investigate the role of AE3 anion exchanger in normal and pathologic heart functions
Sat Jan 01 00:00:00 UTC 2011
Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction.
Cell calcium
Eltit JM,Szpyt J,Li H,Allen PD,Perez CF
MA3-921 was used in Immunofluorescence to suggest that skeletal triadins do not play a direct role in skeletal EC-coupling.
Tue Feb 01 00:00:00 UTC 2011
Reduced gain of excitation-contraction coupling in triadin-null myotubes is mediated by the disruption of FKBP12/RyR1 interaction.
Cell calcium
Eltit JM,Szpyt J,Li H,Allen PD,Perez CF
MA3-921 was used in Immunofluorescence to suggest that skeletal triadins do not play a direct role in skeletal EC-coupling.
Tue Feb 01 00:00:00 UTC 2011
Kir2.6 regulates the surface expression of Kir2.x inward rectifier potassium channels.
The Journal of biological chemistry
Dassau L,Conti LR,Radeke CM,Ptáček LJ,Vandenberg CA
MA3-921 was used in immunohistochemistry to investigate the role of Kir2.6 in regulating the abundance of Kir2 channels on plasma membrane
Fri Mar 18 00:00:00 UTC 2011
Sodium accumulation promotes diastolic dysfunction in end-stage heart failure following Serca2 knockout.
The Journal of physiology
Louch WE,Hougen K,Mørk HK,Swift F,Aronsen JM,Sjaastad I,Reims HM,Roald B,Andersson KB,Christensen G,Sejersted OM
MA3-921 was used in western blot to examine the effects of sodium accumulation on diastolic function following Serca2 knockout
Mon Feb 01 00:00:00 UTC 2010
Delayed enrichment of mesenchymal cells promotes cardiac lineage and calcium transient development.
Journal of molecular and cellular cardiology
Grajales L,García J,Banach K,Geenen DL
MA3-921 was used in flow cytometry and immunocytochemistry to study role of mesenchymal cells in cardiac differential and calcium homeostasis
Thu Apr 01 00:00:00 UTC 2010
Delayed enrichment of mesenchymal cells promotes cardiac lineage and calcium transient development.
Journal of molecular and cellular cardiology
Grajales L,García J,Banach K,Geenen DL
MA3-921 was used in flow cytometry and immunocytochemistry to study role of mesenchymal cells in cardiac differential and calcium homeostasis
Thu Apr 01 00:00:00 UTC 2010
Aerobic exercise training improves Ca2+ handling and redox status of skeletal muscle in mice.
Experimental biology and medicine (Maywood, N.J.)
Ferreira JC,Bacurau AV,Bueno CR,Cunha TC,Tanaka LY,Jardim MA,Ramires PR,Brum PC
MA3-921 was used in western blot to investigate the effect of aerobic exercise on calcium signal and redox state of skeletal muscle
Thu Apr 01 00:00:00 UTC 2010
Aerobic exercise training improves skeletal muscle function and Ca2+ handling-related protein expression in sympathetic hyperactivity-induced heart failure.
Journal of applied physiology (Bethesda, Md. : 1985)
Bueno CR,Ferreira JC,Pereira MG,Bacurau AV,Brum PC
MA3-921 was used in western blot to investigate the effect of aerobic exercise on skeletal muscle function and calcium-related protein expression
Wed Sep 01 00:00:00 UTC 2010
Slowing of cardiomyocyte Ca2+ release and contraction during heart failure progression in postinfarction mice.
American journal of physiology. Heart and circulatory physiology
Mørk HK,Sjaastad I,Sejersted OM,Louch WE
MA3-921 was used in western blot to investigate the effect of the slowing of cardiomyocyte calcium release during congestive heart failure (CHF) progression
Wed Apr 01 00:00:00 UTC 2009
Functional vitamin D receptor (VDR) in the t-tubules of cardiac myocytes: VDR knockout cardiomyocyte contractility.
Endocrinology
Tishkoff DX,Nibbelink KA,Holmberg KH,Dandu L,Simpson RU
Published figure using CACNA2D1 monoclonal antibody (Product # MA3-921) in Western Blot
Fri Feb 01 00:00:00 UTC 2008
S100A1 deficiency results in prolonged ventricular repolarization in response to sympathetic activation.
General physiology and biophysics
Ackermann GE,Domenighetti AA,Deten A,Bonath I,Marenholz I,Pedrazzini T,Erne P,Heizmann CW
MA3-921 was used in western blot to investigate the role of S100A1 in normal heart function
Sun Jun 01 00:00:00 UTC 2008
Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease.
Development (Cambridge, England)
Hirata H,Watanabe T,Hatakeyama J,Sprague SM,Saint-Amant L,Nagashima A,Cui WW,Zhou W,Kuwada JY
MA3-921 was used in immunohistochemistry to study zebrafish relatively relaxed mutants carrying a ryanodine receptor defect as a model of multi-minicore disease
Wed Aug 01 00:00:00 UTC 2007
Increased cardiomyocyte function and Ca2+ transients in mice during early congestive heart failure.
Journal of molecular and cellular cardiology
Mørk HK,Sjaastad I,Sande JB,Periasamy M,Sejersted OM,Louch WE
MA3-921 was used in western blot to investigate the myocardial function in a mouse model of early congestive heart failure
Wed Aug 01 00:00:00 UTC 2007
Reduced expression of regucalcin in young and aged mdx diaphragm indicates abnormal cytosolic calcium handling in dystrophin-deficient muscle.
Biochimica et biophysica acta
Doran P,Dowling P,Donoghue P,Buffini M,Ohlendieck K
MA3-921 was used in western blot to study the reduced regucalcin expression observed in diaphragm muscle in muscular dystrophy and the significance for calcium handling
Sat Apr 01 00:00:00 UTC 2006
Microarray profiling of skeletal muscle sarcoplasmic reticulum proteins.
Biochimica et biophysica acta
Schulz JS,Palmer N,Steckelberg J,Jones SJ,Zeece MG
MA3-921 was used in western blot to investigate the skeletal muscle sarcoplasmic reticulum proteins through microarray analyses
Fri Sep 01 00:00:00 UTC 2006
Daily exercise-induced cardioprotection is associated with changes in calcium regulatory proteins in hypertensive rats.
American journal of physiology. Heart and circulatory physiology
Collins HL,Loka AM,Dicarlo SE
MA3-921 was used in western blot to investigate the association of daily exercise-induced cardioprotection with changes in calcium regulatory proteins in hypertensive rats
Tue Feb 01 00:00:00 UTC 2005
Subcellular localization of the delayed rectifier K(+) channels KCNQ1 and ERG1 in the rat heart.
American journal of physiology. Heart and circulatory physiology
Rasmussen HB,Møller M,Knaus HG,Jensen BS,Olesen SP,Jørgensen NK
MA3-921 was used in immunocytochemistry to investigate the subcellular localization of KCNQ1 and ERG1 in cardiac muscle cells
Thu Apr 01 00:00:00 UTC 2004
Increased sensitivity of the ryanodine receptor to halothane-induced oligomerization in malignant hyperthermia-susceptible human skeletal muscle.
Journal of applied physiology (Bethesda, Md. : 1985)
Glover L,Heffron JJ,Ohlendieck K
MA3-921 was used in western blot to investigate the importance of RyR2 complex formation in the development of a metabolic crisis in malignant hyperthermia
Thu Jan 01 00:00:00 UTC 2004
Visualization of the domain structure of an L-type Ca2+ channel using electron cryo-microscopy.
Journal of molecular biology
Wolf M,Eberhart A,Glossmann H,Striessnig J,Grigorieff N
MA3-921 was used in western blot to conduct structural analysis of an L-type calcium channel
Fri Sep 05 00:00:00 UTC 2003
Comparative analysis of Dp427-deficient mdx tissues shows that the milder dystrophic phenotype of extraocular and toe muscle fibres is associated with a persistent expression of beta-dystroglycan.
European journal of cell biology
Dowling P,Lohan J,Ohlendieck K
MA3-921 was used in western blot to study the relative preservation of beta-dystoglycan in extraocular and toe muscles as the reason of the mild dystrophic phenotype of these tissues in Dp427-defficient muscular dystrophy
Thu May 01 00:00:00 UTC 2003
Ca2+ regulatory systems in rat myocardium are altered by 24 weeks treadmill training.
Pflugers Archiv : European journal of physiology
Morán M,Saborido A,Megías A
MA3-921 was used in western blot to investigate the effect of 24-week treadmill training on the calcium regulatory systems in rat myocardium
Thu May 01 00:00:00 UTC 2003
Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance.
The Journal of biological chemistry
Most P,Remppis A,Pleger ST,Löffler E,Ehlermann P,Bernotat J,Kleuss C,Heierhorst J,Ruiz P,Witt H,Karczewski P,Mao L,Rockman HA,Duncan SJ,Katus HA,Koch WJ
MA3-921 was used in western blot to investigate the role of S100A1 in the regulation of cardiac function in vivo
Fri Sep 05 00:00:00 UTC 2003
Drastic reduction of calsequestrin-like proteins and impaired calcium binding in dystrophic mdx muscle.
Journal of applied physiology (Bethesda, Md. : 1985)
Culligan K,Banville N,Dowling P,Ohlendieck K
MA3-921 was used in western blot to identify the changes in protein expression and calcium homeostasis in dystrophic mdx muscle
Fri Feb 01 00:00:00 UTC 2002
Native skeletal muscle dihydropyridine receptor exists as a supramolecular triad complex.
Cellular and molecular life sciences : CMLS
Froemming GR,Ohlendieck K
MA3-921 was used in western blot to study the structure of the native skeletal muscle dihydropyridine receptor
Thu Feb 01 00:00:00 UTC 2001
Calcium channel alpha(2)delta subunits-structure and Gabapentin binding.
Molecular pharmacology
Marais E,Klugbauer N,Hofmann F
MA3-921 was used in western blot to investigate the structure and properties of the novel alpha 2 delta-2 and -4 subunits
Tue May 01 00:00:00 UTC 2001
Low-frequency stimulation of fast muscle affects the abundance of Ca(2+)-ATPase but not its oligomeric status.
Journal of applied physiology (Bethesda, Md. : 1985)
Harmon S,Froemming GR,Leisner E,Pette D,Ohlendieck K
MA3-921 was used in western blot to investigate the possible effects of stimulation-induced changes in the abundance of calcium pump on protein-protein interactions
Mon Jan 01 00:00:00 UTC 2001
Calsequestrin binds to monomeric and complexed forms of key calcium-handling proteins in native sarcoplasmic reticulum membranes from rabbit skeletal muscle.
Biochimica et biophysica acta
Glover L,Culligan K,Cala S,Mulvey C,Ohlendieck K
MA3-921 was used in western blot to study the binding of calcium handling proteins to calsequestrin in rabbit skeletal muscle sarcoplasmic reticulum membranes
Sat Dec 01 00:00:00 UTC 2001
Comparative analysis of the isoform expression pattern of Ca(2+)-regulatory membrane proteins in fast-twitch, slow-twitch, cardiac, neonatal and chronic low-frequency stimulated muscle fibers.
Biochimica et biophysica acta
Froemming GR,Murray BE,Harmon S,Pette D,Ohlendieck K
MA3-921 was used in western blot to study the expression of Ca(2+) regulatory membrane protein isoforms in skeletal, cardiac and neonatal muscle fibres
Thu Jun 01 00:00:00 UTC 2000
Effects of chronic low-frequency stimulation on Ca2+-regulatory membrane proteins in rabbit fast muscle.
Pflugers Archiv : European journal of physiology
Ohlendieck K,Frömming GR,Murray BE,Maguire PB,Leisner E,Traub I,Pette D
MA3-921 was used in western blot to study the effects of chronic low frequency stimulation of fast-twitch muscle on the levels of Ca(2+) regulatory membrane proteins
Fri Oct 01 00:00:00 UTC 1999
Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle.
The Journal of cell biology
Protasi F,Franzini-Armstrong C,Allen PD
MA3-921 was used in immunohistochemistry to investigate the calcium release apparatus in skeletal muscle
Mon Feb 23 00:00:00 UTC 1998
