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Alomone Labs, LTD
CACNA2D2 (CaV alpha 2 delta 2) (extracellular) Polyclonal Antibody
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FIGURE: 1 / 3
CACNA2D2 (CaV alpha 2 delta 2) (extracellular) Antibody (ACC-102-200UL) in IHC
Expression of CaV alpha 2 delta 2 channel in rat cerebellum - Immunohistochemical staining rat cerebellum using Anti-CACNA2D2 (CaV alpha 2 delta 2) (extracellular) Antibody (#ACC-102). A. CaV alpha 2 delta 2 (green) appears in the soma of Purkinje cells (arrow) and in the molecular layer (M). B. Preincubation of the Antibody with the blocking peptide blocks staining of Purkinje cells and molecular layer. DA... View More
Product Details
ACC-102-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
(C)DLEAWAEKFKVLASNR, corresponding to amino acid residues 850-865 of rat CaV alpha 2 delta 2, Extracellular, N-terminus
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
Target Information
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha 2 delta calcium channel subunit; calcium channel, voltage dependent, alpha2/delta subunit 2; calcium channel, voltage-dependent, alpha 2/delta subunit 2; Cav alpha2/delta2; ducky; gene 26; Protein ducky; Voltage-dependent calcium channel subunit alpha-2/delta-2; Voltage-gated calcium channel subunit alpha-2/delta-2
Gene Aliases: a2d2; CACNA2D; CACNA2D2; du; KIAA0558; mKIAA0558; td; torpid
UniProt ID: (Human) Q9NY47, (Mouse) Q6PHS9, (Rat) Q8CFG6
Entrez Gene ID: (Human) 9254, (Mouse) 56808, (Rat) 300992
transport
ion transport
calcium ion transport
neuromuscular junction development
regulation of ion transmembrane transport
regulation of multicellular organism growth
positive regulation of organ growth
muscle fiber development
regulation of calcium ion transport
rhythmic synaptic transmission
calcium ion transmembrane transport
regulation of insulin secretion
cardiac conduction
Performance Guarantee
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