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Immunogen sequence: STGPVNKSN VVTASTSIQL LDERKSPVVA AVGIQMKLEF FQRKFWTASR QCASLDGKCS ISCDDETVNC YLIDNNGFIL VSEDYTQTGD FFGEIEGAVM NKLLTMGSFK RITLYDYQAM CRANKESSDG AHGLLDPYNA FLSAVKWIMT ELVLFLVEFN LCSWWHSDMT AKAQKLKQTL EPCDTEYPAF VSERTIKETT GNIACEDCSK SFVIQQIPSS NLFMVVVDSS CLCESVAPIT MAPIEIRYNE SLKCERLKAQ KIRRRPESCH GFHPEENARE CGGAPSLQAQ TVLLLLPLLL MLFSR (788-1091 aa encoded by BC137502)
CACNA2D3 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha 2 delta-3; alpha2delta3; calcium channel alpha2-delta3 subunit; calcium channel, voltage dependent, alpha2/delta subunit 3; calcium channel, voltage-dependent, alpha 2/delta 3 subunit; calcium channel, voltage-dependent, alpha 2/delta subunit 3; CaV alpha2delta3; Voltage-dependent calcium channel subunit alpha-2/delta-3; Voltage-gated calcium channel subunit alpha-2/delta-3
Gene Aliases: CACNA2D3; Cacnad3; HSA272268
UniProt ID: (Human) Q8IZS8, (Mouse) Q9Z1L5
Entrez Gene ID: (Human) 55799, (Mouse) 12294
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