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CACNA2D4 Antibody (PA5-88463) in WB
Western blot analysis of CACNA2D4 in extracts of various cell lines. Samples were incubated with CACNA2D4 Polyclonal antibody (Product # PA5-88463) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-88463
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 992-1115 of human CACNA2D4 (NP_7589524)
Conjugate
Form
Liquid
Concentration
3.3 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2804931
Product Specific Information
Immunogen sequence: AKSVFHHSHK HKKQDPLQPC DTEYPVFVYQ PAIREANGIV ECGPCQKVFV VQQIPNSNLL LLVTDPTCDC SIFPPVLQEA TEVKYNASVK CDRMRSQKLR RRPDSCHAFH PEENAQDCGG ASDT; Positive Samples: LO2, Raji; Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
CACNA2D4 is a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium channel, voltage-dependent, alpha 2/delta subunit 4; Voltage-dependent calcium channel subunit alpha-2/delta-4; voltage-gated calcium channel alpha(2)delta-4 subunit; Voltage-gated calcium channel subunit alpha-2/delta-4
Gene Aliases: 5730412N02Rik; BE686333; CACNA2D4; RCD4
UniProt ID: (Human) Q7Z3S7, (Mouse) Q5RJF7
Entrez Gene ID: (Human) 93589, (Mouse) 319734
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