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Product Details
18389-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CACNG1 Fusion Protein Ag12918 (30-184 aa encoded by BC069493)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DHWAVLSPH MEHHNTTCEA AHFGLWRICT KRIPMDDSKT CGPITLPGEK NCSYFRHFNP GESSEIFEFT TQKEYSISAA AIAIFSLGFI ILGSLCVLLS LGKKRDYLLR PASMFYAFAG LCILVSVEVM RQSVKRMIDS EDTVWIEYYY SWSFAC (30-184 aa encoded by BC069493)
Target Information
Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an alpha1 subunit, a beta subunit, a gamma subunit and an alpha2 delta subunit. The beta subunit is encoded by four genes, designated beta1-beta4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the alpha1 subunit. L-type Ca ++ CP gamma1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP gamma1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP gamma1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anesthetics and depolarizing muscle relaxants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium channel, voltage-dependent, gamma subunit 1; Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; L-type calcium channel gamma polypeptide; neuronal dihydropyridine-sensitive calcium channel gamma subunit; Voltage-dependent calcium channel gamma-1 subunit
Gene Aliases: CACNG1; CACNLG
UniProt ID: (Human) Q06432
Entrez Gene ID: (Human) 786
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