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Product Details
PA5-21352
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the C-terminus region of human CAD. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_11155785
Product Specific Information
Recommended positive controls: 293T, C2C12.
Predicted reactivity: Mouse (92%), Rat (92%), Bovine (92%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAD protein; CAD trifunctional protein; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; Multifunctional protein CAD
Gene Aliases: 2410008J01Rik; AU018859; CAD; CDG1Z; Cpad
UniProt ID: (Human) P27708, (Mouse) B2RQC6
Entrez Gene ID: (Human) 790, (Mouse) 69719
aspartate carbamoyltransferase activity
carbamoyl-phosphate synthase (ammonia) activity
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
dihydroorotase activity
protein kinase activity
ATP binding
zinc ion binding
enzyme binding
identical protein binding
aspartate binding
nucleotide binding
UTP binding
catalytic activity
amino acid binding
transferase activity
carboxyl- or carbamoyltransferase activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ligase activity
metal ion binding
urea cycle
'de novo' pyrimidine nucleobase biosynthetic process
pyrimidine nucleotide biosynthetic process
UTP biosynthetic process
cellular amino acid metabolic process
arginine biosynthetic process
glutamine metabolic process
nitrogen compound metabolic process
metabolic process
drug metabolic process
peptidyl-threonine phosphorylation
protein autophosphorylation
liver development
heart development
female pregnancy
lactation
response to amine
response to caffeine
organ regeneration
response to testosterone
cellular response to drug
'de novo' UMP biosynthetic process
pyrimidine nucleoside biosynthetic process
response to cortisol
cellular response to epidermal growth factor stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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