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Invitrogen
CALHM1 Polyclonal Antibody
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CALHM1 Antibody (PA5-109478) in IHC (P)
Immunohistochemistry analysis of CALHM1 in paraffin-embedded rat brain. Samples were incubated with CALHM1 Polyclonal antibody (Product # PA5-109478) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-109478
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 202-346 of human CALHM1 (NP_001001412.3).
Conjugate
Form
Liquid
Concentration
1.46 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2854889
Product Specific Information
Immunogen sequence: VRSVRPCFTQ AAFLKSKYWS HYIDIERKLF DETCTEHAKA FAKVCIQQFF EAMNHDLELG HTHGTLATAP ASAAAPTTPD GAEEEREKLR GITDQGTMNR LLTSWHKCKP PLRLGQEEPP LMGNGWAGGG PRPPRKEVAT YFSKV
Target Information
Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium homeostasis modulator protein 1; family with sequence similarity 26, member C; Protein FAM26C
Gene Aliases: CALHM1; FAM26C; RGD1564891
UniProt ID: (Human) Q8IU99
Entrez Gene ID: (Human) 255022, (Rat) 499367
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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