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Product Details
PA5-113789
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Immunogen sequence: GITDQGTMNR LLTSWHKCKP PLRLGQEAPL MSNGWAGGEP RPPRKEVATY (aa 295-344).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2884304
Product Specific Information
Immunogen sequence: GITDQGTMNR LLTSWHKCKP PLRLGQEAPL MSNGWAGGEP RPPRKEVATY
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 93%; Dog: 93%; Horse: 85%; Human: 100%; Mouse: 93%; Pig: 86%; Rabbit: 93%; Rat: 100%
Target Information
Alzheimers disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium homeostasis modulator protein 1
Gene Aliases: Calhm1; EG546729
UniProt ID: (Mouse) D3Z291
Entrez Gene ID: (Mouse) 546729
transport
ion transport
cation transport
calcium ion transport
ATP transport
ion transmembrane transport
regulation of ion transmembrane transport
sensory perception of bitter taste
sensory perception of sweet taste
sensory perception of umami taste
protein homooligomerization
calcium ion transmembrane transport
cation transmembrane transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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