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OriGene
CAMK2B Monoclonal Antibody (OTI8D9), TrueMAB™
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CAMK2B Antibody (TA808345) in IHC (P)
Immunohistochemical staining of paraffin-embedded human bladder tissue within the normal limits using anti-CAMK2B mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808345)(1:150).
Product Details
TA808345
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI8D9
Immunogen
Human recombinant protein fragment corresponding to amino acids 311-385 of human CAMK2B produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CAMK2B (CaMKII beta) is a serine/threonine kinase that plays a role in synaptic plasticity, synaptic vesicle mobilization and regulation of gene expression. As a dominant kinase in the central nervous system it may function in long term potentiation and neurotransmitter release. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium/calmodulin-dependent protein kinase II beta; Calcium/calmodulin-dependent protein kinase type II subunit beta; CaM kinase II beta subunit; CaM kinase II subunit beta; CaM-kinase II beta chain; caMK-II subunit beta; MGC29528; proline rich calmodulin-dependent protein kinase; β CaMKII; βCaMKII
Gene Aliases: CAM2; CAMK2; CAMK2B; CAMKB
UniProt ID: (Human) Q13554
Entrez Gene ID: (Human) 816
MAPK cascade
protein phosphorylation
signal transduction
positive regulation of neuron projection development
regulation of skeletal muscle adaptation
positive regulation of phospholipase A2 activity
positive regulation of GTPase activity
protein autophosphorylation
regulation of long-term neuronal synaptic plasticity
cell projection morphogenesis
regulation of synapse structural plasticity
regulation of calcium ion transport
interferon-gamma-mediated signaling pathway
regulation of dendritic spine development
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
regulation of cellular response to heat
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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