Proteintech

CAMKK2 Polyclonal Antibody

CAMKK2 Antibody in Immunocytochemistry (ICC/IF)

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CAMKK2 Antibody (11549-1-AP) in ICC/IF

Immunofluorescent analysis of PC-3 cells using 11549-1-AP (CAMKK2 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CAMKK2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

11549-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 25 publications 25 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Immunocytochemistry (ICC/IF)

1:10-1:100

View 5 publications 5 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CAMKK2 Fusion Protein Ag2093 (1-353 aa encoded by BC026060)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSSCVSSQP SSNRAAPQDE LGGRGSSSSE SQKPCEALRG LSSLSIHLGM ESFIVVTECE PGCAVDLGLA RDRPLEADGQ EVPLDSSGSQ ARPHLSGRKL SLQERSQGGL AAGGSLDMNG RCICPSLPYS PVSSPQSSPR LPRRPTVESH HVSITGMQDC VQLNQYTLKD EIGKGSYGVV KLAYNENDNT YYAMKVLSKK KLIRQAGFPR RPPPRGTRPA PGGCIQPRGP IEQVYQEIAI LKKLDHPNVV KLVEVLDDPN EDHLYMVFEL VNQGPVMEVP TLKPLSEDQA RFYFQDLIKG IEYLHYQKII HRDIKPSNLL VGEDGHIKIA DFGVSNEFKG SDALLSNTVG TPAF (1-353 aa encoded by BC026060)

Target Information

CAMKK2 (CaMKK beta) is a serine/threonine kinase involved in neurogenesis, cell differentiation, and signal transduction. It also activates CAMKI and CAMKIV, and plays a role in the development of long term memory.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Frontiers in pharmacology

Wang H,Jia Y,Gu J,Chen O,Yue S

Tue Feb 28 00:00:00 UTC 2023

Qian Yang Yu Yin granule improves hypertensive renal damage: A potential role for TRPC6-CaMKKβ-AMPK-mTOR-mediated autophagy.

Journal of ethnopharmacology

Ma S,Xu J,Zheng Y,Li Y,Wang Y,Li H,Fang Z,Li J

Fri Feb 10 00:00:00 UTC 2023

Qian Yang Yu Yin granule improves hypertensive renal damage: A potential role for TRPC6-CaMKKβ-AMPK-mTOR-mediated autophagy.

Journal of ethnopharmacology

Ma S,Xu J,Zheng Y,Li Y,Wang Y,Li H,Fang Z,Li J

Fri Feb 10 00:00:00 UTC 2023

A high-concentrate diet induces inflammatory injury via regulating Ca²⁺/CaMKKβ-mediated autophagy in mammary gland tissue of dairy cows.

Frontiers in immunology

Meng M,Li X,Wang Z,Huo R,Ma N,Chang G,Shen X

Fri May 19 00:00:00 UTC 2023

CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway.

The Journal of investigative dermatology

Wang S,Yi X,Wu Z,Guo S,Dai W,Wang H,Shi Q,Zeng K,Guo W,Li C

Sat Jan 01 00:00:00 UTC 2022

CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway.

The Journal of investigative dermatology

Wang S,Yi X,Wu Z,Guo S,Dai W,Wang H,Shi Q,Zeng K,Guo W,Li C

Sat Jan 01 00:00:00 UTC 2022

Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control.

Frontiers in pharmacology

Yan M,Jin S,Liu Y,Wang L,Wang Z,Xia T,Chang Q

Fri Apr 01 00:00:00 UTC 2022

Transient Ca²⁺ entry by plasmalogen-mediated activation of receptor potential cation channel promotes AMPK activity.

Frontiers in molecular biosciences

Honsho M,Mawatari S,Fujino T

Tue Nov 22 00:00:00 UTC 2022

β-carotene alleviates LPS-induced inflammation through regulating STIM1/ORAI1 expression in bovine mammary epithelial cells.

International immunopharmacology

Meng M,Huo R,Ma N,Chang G,Shen X

Thu Dec 01 00:00:00 UTC 2022

Calcium/calmodulin-dependent protein kinase kinase 2 mediates pleiotropic effects of epidermal growth factor in cancer cells.

Biochimica et biophysica acta. Molecular cell research

Dai S,Venturini E,Yadav S,Lin X,Clapp D,Steckiewicz M,Gocher-Demske AM,Hardie DG,Edelman AM

Fri Jul 01 00:00:00 UTC 2022

Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Zhong Y,Luo R,Liu Q,Zhu J,Lei M,Liang X,Wang X,Peng X

Sat Jan 01 00:00:00 UTC 2022

m⁶A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Autophagy

Chen Y,Wang J,Xu D,Xiang Z,Ding J,Yang X,Li D,Han X

Mon Feb 01 00:00:00 UTC 2021

m⁶A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells.

Autophagy

Chen Y,Wang J,Xu D,Xiang Z,Ding J,Yang X,Li D,Han X

Mon Feb 01 00:00:00 UTC 2021

Theaflavin Promotes Mitochondrial Abundance and Glucose Absorption in Myotubes by Activating the CaMKK2-AMPK Signal Axis via Calcium-Ion Influx.

Journal of agricultural and food chemistry

Qu Z,Liu A,Liu C,Tang Q,Zhan L,Xiao W,Huang J,Liu Z,Zhang S

Wed Jul 28 00:00:00 UTC 2021

CARS senses cysteine deprivation to activate AMPK for cell survival.

The EMBO journal

Yuan M,Yan R,Zhang Y,Qiu Y,Jiang Z,Liu H,Wang Y,Sun L,Zhang H,Gao P

Tue Nov 02 00:00:00 UTC 2021

A glaucoma- and ALS-associated mutant of OPTN induces neuronal cell death dependent on Tbk1 activity, autophagy and ER stress.

The FEBS journal

Medchalmi S,Tare P,Sayyad Z,Swarup G

Sun Aug 01 00:00:00 UTC 2021

Calcium overload and reactive oxygen species accumulation induced by selenium deficiency promote autophagy in swine small intestine.

Animal nutrition (Zhongguo xu mu shou yi xue hui)

Zheng Y,Guan H,Yang J,Cai J,Liu Q,Zhang Z

Wed Dec 01 00:00:00 UTC 2021

Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca²⁺ homeostasis.

Cell biology and toxicology

Zhong Y,Jin C,Han J,Zhu J,Liu Q,Sun D,Xia X,Peng X

Fri Oct 01 00:00:00 UTC 2021

Macropinocytosis in Cancer-Associated Fibroblasts Is Dependent on CaMKK2/ARHGEF2 Signaling and Functions to Support Tumor and Stromal Cell Fitness.

Cancer discovery

Zhang Y,Recouvreux MV,Jung M,Galenkamp KMO,Li Y,Zagnitko O,Scott DA,Lowy AM,Commisso C

Thu Jul 01 00:00:00 UTC 2021

Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca²⁺ Homeostasis, and Bcl2 Expression.

Molecular nutrition & food research

Zhong Y,Jin C,Han J,Zhu J,Liu Q,Sun D,Xia X,Zhang Y,Peng X

Sun Aug 01 00:00:00 UTC 2021

Yi-Zhi-Fang-Dai Formula Exerts a Protective Effect on the Injury of Tight Junction Scaffold Proteins in Vitro and in Vivo by Mediating Autophagy through Regulation of the RAGE/CaMKKβ/AMPK/mTOR Pathway.

Biological & pharmaceutical bulletin

Chan Y,Chen W,Chen Y,Lv Z,Wan W,Li Y,Zhang C

Tue Aug 24 00:00:00 UTC 2021

Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells.

Chinese journal of integrative medicine

Li W,Jiang YH,Wang Y,Zhao M,Hou GJ,Hu HZ,Zhou L

Wed Jan 01 00:00:00 UTC 2020

Berberine attenuates fructose-induced insulin resistance by stimulating the hepatic LKB1/AMPK/PGC1α pathway in mice.

Pharmaceutical biology

Li Y,Wang B,Shen J,Bai M,Xu E

Tue Dec 01 00:00:00 UTC 2020

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents.

Nature communications

Wang Z,Chen Z,Jiang Z,Luo P,Liu L,Huang Y,Wang H,Wang Y,Long L,Tan X,Liu D,Jin T,Wang Y,Wang Y,Liao F,Zhang C,Chen L,Gan Y,Liu Y,Yang F,Huang C,Miao H,Chen J,Cheng T,Fu X,Shi C

Mon Jun 10 00:00:00 UTC 2019

CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.

Cell metabolism

Li Q,Wang Y,Wu S,Zhou Z,Ding X,Shi R,Thorne RF,Zhang XD,Hu W,Wu M

Tue Jul 02 00:00:00 UTC 2019

Paeoniflorin protects against intestinal ischemia/reperfusion by activating LKB1/AMPK and promoting autophagy.

Pharmacological research

Wen J,Xu B,Sun Y,Lian M,Li Y,Lin Y,Chen D,Diao Y,Almoiliqy M,Wang L

Thu Aug 01 00:00:00 UTC 2019

Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways.

Nutrients

Li YC,Qiao JY,Wang BY,Bai M,Shen JD,Cheng YX

Sun Aug 05 00:00:00 UTC 2018

Paeoniflorin Ameliorates Fructose-Induced Insulin Resistance and Hepatic Steatosis by Activating LKB1/AMPK and AKT Pathways.

Nutrients

Li YC,Qiao JY,Wang BY,Bai M,Shen JD,Cheng YX

Sun Aug 05 00:00:00 UTC 2018

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

Nature

Zhang CS,Hawley SA,Zong Y,Li M,Wang Z,Gray A,Ma T,Cui J,Feng JW,Zhu M,Wu YQ,Li TY,Ye Z,Lin SY,Yin H,Piao HL,Hardie DG,Lin SC

Thu Aug 03 00:00:00 UTC 2017

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK.

Nature

Zhang CS,Hawley SA,Zong Y,Li M,Wang Z,Gray A,Ma T,Cui J,Feng JW,Zhu M,Wu YQ,Li TY,Ye Z,Lin SY,Yin H,Piao HL,Hardie DG,Lin SC

Thu Aug 03 00:00:00 UTC 2017

Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues.

Toxicology

Wang S,Chen Y,Kou R,Wang Y,Zeng T,Xie K,Song F

Wed Aug 10 00:00:00 UTC 2016

Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues.

Toxicology

Wang S,Chen Y,Kou R,Wang Y,Zeng T,Xie K,Song F

Wed Aug 10 00:00:00 UTC 2016

Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells.

Oncotarget

Zhao F,Huang W,Zhang Z,Mao L,Han Y,Yan J,Lei M

Tue Feb 02 00:00:00 UTC 2016

Triptolide induces protective autophagy through activation of the CaMKKβ-AMPK signaling pathway in prostate cancer cells.

Oncotarget

Zhao F,Huang W,Zhang Z,Mao L,Han Y,Yan J,Lei M

Tue Feb 02 00:00:00 UTC 2016

Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.

The Biochemical journal

Knight JR,Bastide A,Roobol A,Roobol J,Jackson TJ,Utami W,Barrett DA,Smales CM,Willis AE

Thu Jan 15 00:00:00 UTC 2015

Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation.

The Biochemical journal

Knight JR,Bastide A,Roobol A,Roobol J,Jackson TJ,Utami W,Barrett DA,Smales CM,Willis AE

Thu Jan 15 00:00:00 UTC 2015

Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKKβ/AMPK/ACC Pathway.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Xi Y,Wu M,Li H,Dong S,Luo E,Gu M,Shen X,Jiang Y,Liu Y,Liu H

Mon Feb 08 00:00:00 UTC 2016

Baicalin Attenuates High Fat Diet-Induced Obesity and Liver Dysfunction: Dose-Response and Potential Role of CaMKKβ/AMPK/ACC Pathway.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

Xi Y,Wu M,Li H,Dong S,Luo E,Gu M,Shen X,Jiang Y,Liu Y,Liu H

Mon Feb 08 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: calcium/calmodulin-dependent protein kinase beta; Calcium/calmodulin-dependent protein kinase kinase 2; calcium/calmodulin-dependent protein kinase kinase 2, beta; Calcium/calmodulin-dependent protein kinase kinase beta; caM-kinase kinase 2; caM-kinase kinase beta; CaM-KK 2; CaM-KK beta; caMKK 2; caMKK beta; CAMKK beta protein; MGC15254

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Gene Aliases: 6330570N16Rik; AW061083; CAMKK; CAMKK2; CAMKKB; KIAA0787; mKIAA0787

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UniProt ID: (Human) Q96RR4, (Mouse) Q8C078

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Entrez Gene ID: (Human) 10645, (Mouse) 207565

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Function(s)

calmodulin-dependent protein kinase activity protein tyrosine kinase activity calcium ion binding calmodulin binding ATP binding nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

MAPK cascade protein phosphorylation peptidyl-tyrosine phosphorylation calcium-mediated signaling regulation of protein kinase activity positive regulation of transcription, DNA-templated protein autophosphorylation phosphorylation activation of protein kinase activity

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CAMKK2 Polyclonal Antibody

CAMKK2 Antibody (11549-1-AP) in ICC/IF

Product Details

11549-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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