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Invitrogen
CAMSAP1 Polyclonal Antibody
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Product Details
PA5-116776
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 350-650 of human CAMSAP1 (NP_0562623)
Conjugate
Form
Liquid
Concentration
2.83 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901407
Product Specific Information
Positive Samples: HeLa
Immunogen sequence: KTVLHQKSSR PPVPISNATK RSFLGSPAAG TLAELQPPVQ LPAEGCHRHY LHPEEPEYLG KGTAAFSPSH PLLPLRQKQQ KSIQGEDIPD QRHRSNSLTR VDGQPRGAAI AWPEKKTRPA SQPTPFALHH AASCEVDPSS GDSISLARSI SKDSLASNIV NLTPQNQPHP TATKSHGKSL LSNVSIEDEE EELVAIVRAD VVPQQADPEF PRASPRALGL TANARSPQGQ LDTSESKPDS FFLEPLMPAV LKPAKEKQVI TKEDERGEGR PRSIVSRRPS EGPQPLVRRK MTGSRDLNRT F
Target Information
Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:19508979, PubMed:21834987, PubMed:24486153, PubMed:24706919, PubMed:24117850). Specifically recognizes growing microtubule minus-ends and stabilizes microtubules (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In contrast to CAMSAP2 and CAMSAP3, tracks along the growing tips of minus-end microtubules without significantly affecting the polymerization rate: binds at the very tip of the microtubules minus-end and acts as a minus-end tracking protein (-TIP) that dissociates from microtubules after allowing tubulin incorporation (PubMed:24486153, PubMed:24706919). Through interaction with spectrin may regulate neurite outgrowth (PubMed:24117850). [UniProt]
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calmodulin-regulated spectrin-associated protein 1; DKFZp434F195; FLJ31228
Gene Aliases: 9530003A05Rik; C77823; CAMSAP1; PRO2405
UniProt ID: (Human) Q5T5Y3, (Mouse) A2AHC3
Entrez Gene ID: (Human) 157922, (Mouse) 227634
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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