Proteintech

CAPG Polyclonal Antibody

CAPG Antibody in Immunocytochemistry (ICC/IF)

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CAPG Antibody (10194-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells, using CAPG antibody 10194-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

CAPG Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CAPG Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10194-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 19 publications 19 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CAPG Fusion Protein Ag0248 (62-349 aa encoded by BC000728)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: HLWIGQQSS RDEQGACAVL AVHLNTLLGE RPVQHREVQG NESDLFMSYF PRGLKYQEGG VESAFHKTST GAPAAIKKLY QVKGKKNIRA TERALNWDSF NTGDCFILDL GQNIFAWCGG KSNILERNKA RDLALAIRDS ERQGKAQVEI VTDGEEPAEM IQVLGPKPAL KEGNPEEDLT ADKANAQAAA LYKVSDATGQ MNLTKVADSS PFALELLISD DCFVLDNGLC GKIYIWKGRK ANEKERQAAL QVAEGFISRM QYAPNTQVEI LPQGRESPIF KQFFKDWK (62-349 aa encoded by BC000728 )

Target Information

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively spliced transcript variants have been observed, but have not been fully described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Deposition of platelet-derived microparticles in podocytes contributes to diabetic nephropathy.

International urology and nephrology

Huang SJ,Zhang Y,Wang GH,Lu J,Chen PP,Zhang JX,Li XQ,Yuan BY,Liu XQ,Jiang TT,Wang MY,Liu WT,Ruan XZ,Liu BC,Ma KL

Wed Feb 01 00:00:00 UTC 2023

Facile discovery of red blood cell deformation and compromised membrane/skeleton assembly in Prader-Willi syndrome.

Frontiers of medicine

Yang Y,Li G,Wang Y,Sun Y,Xu C,Wei Z,Zhang S,Gao L,Liu S,Zhao J

Thu Dec 01 00:00:00 UTC 2022

CAPG Is Required for Ebola Virus Infection by Controlling Virus Egress from Infected Cells.

Viruses

Mori H,Connell JP,Donahue CJ,Boytz R,Nguyen YTK,Leung DW,LaCount DJ,Davey RA

Sun Aug 28 00:00:00 UTC 2022

CAPG Is Required for Ebola Virus Infection by Controlling Virus Egress from Infected Cells.

Viruses

Mori H,Connell JP,Donahue CJ,Boytz R,Nguyen YTK,Leung DW,LaCount DJ,Davey RA

Sun Aug 28 00:00:00 UTC 2022

Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.

Journal of molecular and cellular cardiology

Wang X,Pierre V,Liu C,Senapati S,Park PS,Senyo SE

Fri Oct 01 00:00:00 UTC 2021

Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.

Journal of molecular and cellular cardiology

Wang X,Pierre V,Liu C,Senapati S,Park PS,Senyo SE

Fri Oct 01 00:00:00 UTC 2021

Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.

Journal of molecular and cellular cardiology

Wang X,Pierre V,Liu C,Senapati S,Park PS,Senyo SE

Fri Oct 01 00:00:00 UTC 2021

Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.

Journal of molecular and cellular cardiology

Wang X,Pierre V,Liu C,Senapati S,Park PS,Senyo SE

Fri Oct 01 00:00:00 UTC 2021

Analysis of a Sardinian Multiplex Family with Autism Spectrum Disorder Points to Post-Synaptic Density Gene Variants and Identifies CAPG as a Functionally Relevant Candidate Gene.

Journal of clinical medicine

Bacchelli E,Loi E,Cameli C,Moi L,Vega-Benedetti AF,Blois S,Fadda A,Bonora E,Mattu S,Fadda R,Chessa R,Maestrini E,Doneddu G,Zavattari P

Thu Feb 07 00:00:00 UTC 2019

Functional analysis of the CXCR1a gene response to SGIV viral infection in grouper.

Fish & shellfish immunology

Wang Q,Yang M,Li C,Wang S,Wang Y,Lin F,Zheng L,Yu Y,Qin Q

Wed May 01 00:00:00 UTC 2019

Function of the macrophage-capping protein in colorectal carcinoma.

Oncology letters

Wu W,Chen J,Ding Q,Yang S,Wang J,Yu H,Lin J

Wed Nov 01 00:00:00 UTC 2017

Function of the macrophage-capping protein in colorectal carcinoma.

Oncology letters

Wu W,Chen J,Ding Q,Yang S,Wang J,Yu H,Lin J

Wed Nov 01 00:00:00 UTC 2017

Function of the macrophage-capping protein in colorectal carcinoma.

Oncology letters

Wu W,Chen J,Ding Q,Yang S,Wang J,Yu H,Lin J

Wed Nov 01 00:00:00 UTC 2017

Function of the macrophage-capping protein in colorectal carcinoma.

Oncology letters

Wu W,Chen J,Ding Q,Yang S,Wang J,Yu H,Lin J

Wed Nov 01 00:00:00 UTC 2017

Effects of quercetin on the expression of MCP-1, MMP-9 and VEGF in rats with diabetic retinopathy.

Experimental and therapeutic medicine

Chen B,He T,Xing Y,Cao T

Fri Dec 01 00:00:00 UTC 2017

Effects of quercetin on the expression of MCP-1, MMP-9 and VEGF in rats with diabetic retinopathy.

Experimental and therapeutic medicine

Chen B,He T,Xing Y,Cao T

Fri Dec 01 00:00:00 UTC 2017

Gelsolin-like actin-capping protein is associated with patient prognosis, cellular apoptosis and proliferation in prostate cancer.

Biomarkers in medicine

Li T,Hong X,Zhao J,Teng Y,Zheng J,Chen H,Chen H,Li H

Thu Dec 01 00:00:00 UTC 2016

Gelsolin-like actin-capping protein is associated with patient prognosis, cellular apoptosis and proliferation in prostate cancer.

Biomarkers in medicine

Li T,Hong X,Zhao J,Teng Y,Zheng J,Chen H,Chen H,Li H

Thu Dec 01 00:00:00 UTC 2016

Propofol Attenuates Lipopolysaccharide-Induced Monocyte Chemoattractant Protein-1 Production Through Enhancing apoM and foxa2 Expression in HepG2 Cells.

Inflammation

Ma X,Zhao JY,Zhao ZL,Ye J,Li SF,Fang HH,Gu MN,Hu YW,Qin ZS

Tue Feb 23 00:00:00 UTC 2016

Propofol Attenuates Lipopolysaccharide-Induced Monocyte Chemoattractant Protein-1 Production Through Enhancing apoM and foxa2 Expression in HepG2 Cells.

Inflammation

Ma X,Zhao JY,Zhao ZL,Ye J,Li SF,Fang HH,Gu MN,Hu YW,Qin ZS

Tue Feb 23 00:00:00 UTC 2016

Differential proteomic analysis of synovial fluid from rheumatoid arthritis and osteoarthritis patients.

Clinical proteomics

Balakrishnan L,Bhattacharjee M,Ahmad S,Nirujogi RS,Renuse S,Subbannayya Y,Marimuthu A,Srikanth SM,Raju R,Dhillon M,Kaur N,Jois R,Vasudev V,Ramachandra Y,Sahasrabuddhe NA,Prasad TsK,Mohan S,Gowda H,Shankar S,Pandey A

Mon Jan 06 00:00:00 UTC 2014

Differential proteomic analysis of synovial fluid from rheumatoid arthritis and osteoarthritis patients.

Clinical proteomics

Mon Jan 06 00:00:00 UTC 2014

Acquisition of useful sero-diagnostic autoantibodies using the same patients'sera and tumor tissues.

Biomedical research (Tokyo, Japan)

Kobayashi M,Nagashio R,Ryuge S,Murakami Y,Yanagita K,Nakashima H,Matsumoto T,Jiang SX,Saegusa M,Satoh Y,Masuda N,Sato Y

Thu Dec 04 00:00:00 UTC 2014

Acquisition of useful sero-diagnostic autoantibodies using the same patients'sera and tumor tissues.

Biomedical research (Tokyo, Japan)

Kobayashi M,Nagashio R,Ryuge S,Murakami Y,Yanagita K,Nakashima H,Matsumoto T,Jiang SX,Saegusa M,Satoh Y,Masuda N,Sato Y

Thu Dec 04 00:00:00 UTC 2014

Acquisition of useful sero-diagnostic autoantibodies using the same patients'sera and tumor tissues.

Biomedical research (Tokyo, Japan)

Kobayashi M,Nagashio R,Ryuge S,Murakami Y,Yanagita K,Nakashima H,Matsumoto T,Jiang SX,Saegusa M,Satoh Y,Masuda N,Sato Y

Thu Dec 04 00:00:00 UTC 2014

Acquisition of useful sero-diagnostic autoantibodies using the same patients'sera and tumor tissues.

Biomedical research (Tokyo, Japan)

Kobayashi M,Nagashio R,Ryuge S,Murakami Y,Yanagita K,Nakashima H,Matsumoto T,Jiang SX,Saegusa M,Satoh Y,Masuda N,Sato Y

Thu Dec 04 00:00:00 UTC 2014

Laser microdissection and two-dimensional difference gel electrophoresis reveal the role of a novel macrophage-capping protein in lymph node metastasis in gastric cancer.

Journal of proteome research

Ichikawa H,Kanda T,Kosugi S,Kawachi Y,Sasaki H,Wakai T,Kondo T

Fri Aug 02 00:00:00 UTC 2013

Laser microdissection and two-dimensional difference gel electrophoresis reveal the role of a novel macrophage-capping protein in lymph node metastasis in gastric cancer.

Journal of proteome research

Ichikawa H,Kanda T,Kosugi S,Kawachi Y,Sasaki H,Wakai T,Kondo T

Fri Aug 02 00:00:00 UTC 2013

Proteomic identification of the macrophage-capping protein as a protein contributing to the malignant features of hepatocellular carcinoma.

Journal of proteomics

Kimura K,Ojima H,Kubota D,Sakumoto M,Nakamura Y,Tomonaga T,Kosuge T,Kondo T

Mon Jan 14 00:00:00 UTC 2013

Proteomic identification of the macrophage-capping protein as a protein contributing to the malignant features of hepatocellular carcinoma.

Journal of proteomics

Kimura K,Ojima H,Kubota D,Sakumoto M,Nakamura Y,Tomonaga T,Kosuge T,Kondo T

Mon Jan 14 00:00:00 UTC 2013

Macrophage-capping protein as a tissue biomarker for prediction of response to gemcitabine treatment and prognosis in cholangiocarcinoma.

Journal of proteomics

Morofuji N,Ojima H,Onaya H,Okusaka T,Shimada K,Sakamoto Y,Esaki M,Nara S,Kosuge T,Asahina D,Ushigome M,Hiraoka N,Nagino M,Kondo T

Thu Feb 16 00:00:00 UTC 2012

Macrophage-capping protein as a tissue biomarker for prediction of response to gemcitabine treatment and prognosis in cholangiocarcinoma.

Journal of proteomics

Morofuji N,Ojima H,Onaya H,Okusaka T,Shimada K,Sakamoto Y,Esaki M,Nara S,Kosuge T,Asahina D,Ushigome M,Hiraoka N,Nagino M,Kondo T

Thu Feb 16 00:00:00 UTC 2012

Macrophage-capping protein as a tissue biomarker for prediction of response to gemcitabine treatment and prognosis in cholangiocarcinoma.

Journal of proteomics

Morofuji N,Ojima H,Onaya H,Okusaka T,Shimada K,Sakamoto Y,Esaki M,Nara S,Kosuge T,Asahina D,Ushigome M,Hiraoka N,Nagino M,Kondo T

Thu Feb 16 00:00:00 UTC 2012

Macrophage-capping protein as a tissue biomarker for prediction of response to gemcitabine treatment and prognosis in cholangiocarcinoma.

Journal of proteomics

Morofuji N,Ojima H,Onaya H,Okusaka T,Shimada K,Sakamoto Y,Esaki M,Nara S,Kosuge T,Asahina D,Ushigome M,Hiraoka N,Nagino M,Kondo T

Thu Feb 16 00:00:00 UTC 2012

Quantitative protein and mRNA profiling shows selective post-transcriptional control of protein expression by vasopressin in kidney cells.

Molecular & cellular proteomics : MCP

Khositseth S,Pisitkun T,Slentz DH,Wang G,Hoffert JD,Knepper MA,Yu MJ

Sat Jan 01 00:00:00 UTC 2011

Quantitative protein and mRNA profiling shows selective post-transcriptional control of protein expression by vasopressin in kidney cells.

Molecular & cellular proteomics : MCP

Khositseth S,Pisitkun T,Slentz DH,Wang G,Hoffert JD,Knepper MA,Yu MJ

Sat Jan 01 00:00:00 UTC 2011

Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia.

American journal of respiratory cell and molecular biology

Zhang R,Zhou L,Li Q,Liu J,Yao W,Wan H

Thu Oct 01 00:00:00 UTC 2009

Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia.

American journal of respiratory cell and molecular biology

Zhang R,Zhou L,Li Q,Liu J,Yao W,Wan H

Thu Oct 01 00:00:00 UTC 2009

Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells.

Proteomics

Liao SH,Zhao XY,Han YH,Zhang J,Wang LS,Xia L,Zhao KW,Zheng Y,Guo M,Chen GQ

Sat Aug 01 00:00:00 UTC 2009

Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells.

Proteomics

Liao SH,Zhao XY,Han YH,Zhang J,Wang LS,Xia L,Zhao KW,Zheng Y,Guo M,Chen GQ

Sat Aug 01 00:00:00 UTC 2009

MnSOD marks cord blood late outgrowth endothelial cells and accompanies robust resistance to oxidative stress.

Biochemical and biophysical research communications

Cai H,Gehrig P,Scott TM,Zimmermann R,Schlapbach R,Zisch AH

Fri Nov 17 00:00:00 UTC 2006

MnSOD marks cord blood late outgrowth endothelial cells and accompanies robust resistance to oxidative stress.

Biochemical and biophysical research communications

Cai H,Gehrig P,Scott TM,Zimmermann R,Schlapbach R,Zisch AH

Fri Nov 17 00:00:00 UTC 2006

Bioinformatics

Protein Aliases: Actin regulatory protein CAP-G; actin-capping protein GCAP39; actin-regulatory protein CAP-G; capping protein (actin filament), gelsolin-like; epididymis secretory protein Li 66; gelsolin-like capping protein; macrophage capping protein; Macrophage-capping protein; myc basic motif homolog 1

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Gene Aliases: AFCP; CAPG; gCap39; HEL-S-66; mbh1; MCP

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UniProt ID: (Human) P40121, (Rat) Q6AYC4

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Entrez Gene ID: (Human) 822, (Rat) 297339, (Mouse) 12332

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Function(s)

actin binding protein binding protein domain specific binding protein complex binding cadherin binding involved in cell-cell adhesion

Process(es)

cell projection assembly barbed-end actin filament capping protein complex assembly extracellular matrix disassembly positive regulation of podosome assembly cell-cell adhesion actin filament capping

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CAPG Polyclonal Antibody

CAPG Antibody (10194-1-AP) in ICC/IF

Product Details

10194-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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