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Proteintech
CAPN3 Monoclonal Antibody (1G12A5)
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Product Details
67366-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
1G12A5
Immunogen
CAPN3 Fusion Protein Ag13179
Conjugate
Form
Liquid
Concentration
1000 µg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
Calpain, an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, plays a role in cytoskeletal reorganization and muscle protein degradation. Calpain is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits, designated calpain 1, calpain 2 and calpain 3. Calpain 3 (calpain p94) is a muscle-preferred calcium activated neutral protease that localizes to the nucleus. Mutations involving the calpain 3 gene are associated with limb-girdle muscle dystrophy type 2A, a form of autosomal recessive and progressive neuromuscular diso4. Calpastatin regulates calpain by inhibiting both the proteolytic activity of calpain and its binding to membranes. Calpastatin exists in two types, tissue type and erythrocyte type, resulting from both alternative splicing and proteolytic processing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calcium-activated neutral proteinase 3; calpain 3, (p94); Calpain L3; Calpain p94; calpain p94, large [catalytic] subunit; calpain, large polypeptide L3; Calpain-3; CANP 3; CAPN 3; LGMD 2A; MGC10767; MGC11121; MGC14344; MGC4403; Muscle-specific calcium-activated neutral protease 3; muscle-specific calcium-activated neutral protease 3 large subunit; nCL-1; New calpain 1; skeletal muscle specific calpain; skeletal muscle specific calpain p94
Gene Aliases: AI323605; CANP3; CANPL3; Capa-3; Capa3; CAPN3; LGMD2; LGMD2A; Lp82; Lp84; Lp85; nCL-1; NCL1; p94
UniProt ID: (Pig) P43368, (Human) P20807, (Mouse) Q64691, (Rat) P16259
Entrez Gene ID: (Pig) 397349, (Human) 825, (Mouse) 12335, (Rat) 29155
catalytic activity
calcium-dependent cysteine-type endopeptidase activity
signal transducer activity
calcium ion binding
protein binding
peptidase activity
cysteine-type peptidase activity
structural constituent of muscle
sodium ion binding
titin binding
protein complex scaffold
ligase regulator activity
receptor binding
hydrolase activity
enzyme binding
metal ion binding
autolysis
protein complex assembly
proteolysis
positive regulation of satellite cell activation involved in skeletal muscle regeneration
response to muscle activity
myofibril assembly
negative regulation of protein sumoylation
negative regulation of apoptotic process
regulation of I-kappaB kinase/NF-kappaB signaling
sarcomere organization
regulation of myoblast differentiation
positive regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
regulation of catalytic activity
positive regulation of NF-kappaB transcription factor activity
positive regulation of release of sequestered calcium ion into cytosol
response to calcium ion
muscle structure development
G1 to G0 transition involved in cell differentiation
cellular response to calcium ion
cellular response to salt stress
protein localization to membrane
self proteolysis
sodium-dependent self proteolysis
response to drug
apoptotic process
signal transduction
muscle organ development
muscle cell cellular homeostasis
negative regulation of skeletal muscle cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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