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Invitrogen
CARF Polyclonal Antibody
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Product Details
PA5-106603
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CARF(Accession Q8N187), corresponding to amino acid residues Y311-A361.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2854271
Product Specific Information
Antibody detects endogenous levels of total ALS2CR8.
Target Information
CARF (calcium-response factor), also known as ALS2CR8 (amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) or NYD-SP24, is a 725 amino acid nuclear protein. Expressed in a wide variety of tissues with highest expression in the hippocampus, CARF is thought to be a transcription factor that associates with the p53 tumor suppression pathway. CARF cooperates, co-localizes and is co-regulated with ARF, an ADP-ribosylation factor, and, through this interaction, helps to mediate ARF-p53-induced apoptotic signaling. This apoptotic pathway is implicated in cell cycle control, proper cellular development, response to DNA damage and the aging process, suggesting that CARF participates in various events throughout the cell.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein homolog; Calcium-response factor; calcium-response factor CaRF; Calcium-responsive transcription factor; CaRF; Testis development protein NYD-SP24
Gene Aliases: ALS2CR8; CARF; ECBRC-FC1; ECBRC-FC2; NYD-SP24
UniProt ID: (Human) Q8N187, (Mouse) Q8VHI4
Entrez Gene ID: (Human) 79800, (Mouse) 241066
transcription from RNA polymerase II promoter
cellular response to potassium ion
positive regulation of transcription from RNA polymerase II promoter in response to calcium ion
cellular response to calcium ion
transcription, DNA-templated
regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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