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Abnova
CARF Monoclonal Antibody (2E6)
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Product Details
H00055602-M04
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
2E6
Immunogen
CARF (AAH22270, 1 a.a. approximately 579 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MAQEVSEYLS QNPRVAAWVE ALRCDGETDK HWRHRRDFLL RNAGDLAPAG GAASASTDEA ADAESGTRNR QLQQLISFSM AWANHVFLGC RYPQKVMDKI LSMAEGIKVT DAPTYTTRDE LVAKVKKRGI SSSNEGVEEP SKKRVIEGKN SSAVEQDHAK TSAKTERASA QQENSSTCIG SAIKSESGNS ARSSGISSQN SSTSDGDRSV SSQSSSSVSS QVTTAGSGKA SEAEAPDKHG SSFVSLLKSS VNSHMTQSTD SRQQSGSPKK SALEGSSASA SQSSSEIEVP LLGSSGSSEV ELPLLSSKPS SETASSGLTS KTSSEASVSS SVAKNSSSSG TSLLTPKSSS STNTSLLTSK STSQVAASLL ASKSSSQTSG SLVSKSTSLA SVSQLASKSS SQTSTSQLPS KSTSQSSESS VKFSCKLTNE DVKQKQPFFN RLYKTVAWKL VAVGGFSPNV NHGELLNAAI EALKATLDVF FVPLKELADL PQNKSSQESI VCELRCKSVY LGTGCGKSKE NAKAVASREA LKLFLKKKVV VKICKRKYRG SEIEDLVLLD EESRPVNLPP ALKHPQELL
Target Information
CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. The p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDKN2A-interacting protein; collaborates/cooperates with ARF (alternate reading frame) protein; Collaborator of ARF
Gene Aliases: CARF; CDKN2AIP
UniProt ID: (Human) Q9NXV6
Entrez Gene ID: (Human) 55602
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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