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Invitrogen
CASK Monoclonal Antibody (A1C5)
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CASK Antibody (MA5-36121) in IHC (P)
Immunohistochemical analysis of CASK in paraffin-embedded human prostate cancer tissue using a monoclonal antibody (Product #MA5-36121). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:50) for 30 mi... View More
Product Details
MA5-36121
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
A1C5
Immunogen
Recombinant protein within Human CASK aa 311-513
Conjugate
Form
Liquid
Concentration
2 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2890427
Target Information
CASK is a calcium/calmodulin-dependent serine protein kinase which is a MAGUK (membrane-associated guanylate kinase) protein family member. CASK is a scaffold protein and the encoded protein is located at synapses in the brain. CASK associates with FG syndrome 4, mental retardation, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked mental retardation. CASK functions as a cytoskeletal membrane scaffold that coordinates signal transduction pathways within the cortical cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: calcium/calmodulin-dependent serin protein kinase; Calcium/calmodulin-dependent serine protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; hCASK; MGC7449; OTTHUMP00000023157; OTTHUMP00000023161; OTTHUMP00000023162; Peripheral plasma membrane protein CASK; Protein lin-2 homolog; RP23-278L4.1; trinucleotide repeat containing 8
Gene Aliases: CAGH39; CAMGUK; CASK; CMG; DXPri1; DXRib1; FGS4; LIN-2; LIN2; MICPCH; mLin-2; MRXSNA; Pals3; TNRC8
UniProt ID: (Human) O14936, (Rat) Q62915, (Mouse) O70589
Entrez Gene ID: (Human) 8573, (Rat) 29647, (Mouse) 12361
guanylate kinase activity
protein serine/threonine kinase activity
protein binding
calmodulin binding
ATP binding
neurexin family protein binding
transcription coactivator activity
calmodulin-dependent protein kinase activity
G-protein coupled receptor activity
protein C-terminus binding
PDZ domain binding
protein complex binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
negative regulation of cell-matrix adhesion
protein complex assembly
protein phosphorylation
intracellular protein transport
G-protein coupled receptor signaling pathway
negative regulation of keratinocyte proliferation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of wound healing
calcium ion import
positive regulation of calcium ion import
negative regulation of cellular response to growth factor stimulus
regulation of nucleic acid-templated transcription
phosphorylation
cell adhesion
neurotransmitter secretion
GMP metabolic process
GDP metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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