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Product Details
OSC00276W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from aa region 2-50 of mouse CATSPER1 conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: CATSPER1.
Target Information
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cation channel of sperm 1; Cation channel sperm-associated protein 1; CatSper1; sperm ion channel; sperm protein CATSPER1
Gene Aliases: Catsper; Catsper1; KSper
UniProt ID: (Mouse) Q91ZR5
Entrez Gene ID: (Mouse) 225865
transport
ion transport
calcium ion transport
multicellular organism development
spermatogenesis
fusion of sperm to egg plasma membrane
cell differentiation
sperm motility
regulation of ion transmembrane transport
regulation of calcium ion transport
transmembrane transport
regulation of cilium beat frequency involved in ciliary motility
calcium ion import
calcium ion transmembrane transport
membrane depolarization during action potential
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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