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Proteintech
CBFA2T3 Polyclonal Antibody
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Product Details
17190-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CBFA2T3 Fusion Protein Ag9265 (167-615 aa encoded by BC062624)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KRRTPDRTK ENGSDRDPLH PQRYSPSNGP PQPTPPPHYR LEDIAMAHHF RDAYRHPDPR ELRERHRPLV VPGSRQEEVI DHKLTEREWA EEWKHLNNLL NCIMDMVEKT RRSLTVLRRC QEADREELNH WARRYSDAED TKKGPAPAAA RPRSSSAGPE GPQLDVPREF LPRTLTGYVP EDIWRKAEEA VNEVKRQAMS ELQKAVSDAE RKAHELITTE RAKMERALAE AKRQASEDAL TVINQQEDSS ESCWNCGRKA SETCSGCNAA RYCGSFCQHR DWEKHHHVCG QSLQGPTAVV ADPVPGPPEA AHSLGPSLPV GAASPSEAGS AGPSRPGSPS PPGPLDTVPR (167-615 aa encoded by BC062624)
Target Information
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16;21)(q24;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: core-binding factor, runt domain, alpha subunit 2; translocated to, 3; Eight twenty one protein 2; ETO/MTG8-related protein ETO-2; hMTG16; MTG16HEL; MTG8-related gene 2; MTG8-related protein 2; myeloid translocation gene 8 and 16b; Myeloid translocation gene on chromosome 16 protein; myeloid translocation gene-related protein 2; Protein CBFA2T3; Protein ETO-2; translocated to, 3; Zinc finger MYND domain-containing protein 4
Gene Aliases: A630044F12Rik; AI465270; AW229127; CBFA2T3; Cbfa2t3h; ETO-2; ETO2; MTG16; MTGR2; RUNX1T3; ZMYND4
UniProt ID: (Human) O75081, (Mouse) O54972
Entrez Gene ID: (Human) 863, (Mouse) 12398, (Rat) 361431
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
cell differentiation
granulocyte differentiation
negative regulation of nucleic acid-templated transcription
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
response to hypoxia
cell proliferation
negative regulation of cell proliferation
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of glycolytic process
regulation of aerobic respiration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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