Proteintech

CBX3 Polyclonal Antibody

CBX3 Antibody in Immunocytochemistry (ICC/IF)

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CBX3 Antibody (11650-2-AP) in ICC/IF

Immunofluorescent analysis of ( 4% PFA ) fixed HepG2 cells using 11650-2-AP (CBX3 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

CBX3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CBX3 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

11650-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 17 publications 17 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:50-1:500

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

ChIP assay (ChIP)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CBX3 Fusion Protein Ag2251 (1-183 aa encoded by BC000954)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MASNKTTLQ KMGKKQNGKS KKVEEAEPEE FVVEKVLDRR VVNGKVEYFL KWKGFTDADN TWEPEENLDC PELIEAFLNS QKAGKEKDGT KRKSLSDSES DDSKSKKKRD AADKPRGFAR GLDPERIIGA TDSSGELMFL MKWKDSDEAD LVLAKEANMK CPQIVIAFYE ERLTWHSCPE DEAQ (1-183 aa encoded by BC000954)

Target Information

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Retrospective analysis of enhancer activity and transcriptome history.

Nature biotechnology

Boers R,Boers J,Tan B,van Leeuwen ME,Wassenaar E,Sanchez EG,Sleddens E,Tenhagen Y,Mulugeta E,Laven J,Creyghton M,Baarends W,van IJcken WFJ,Gribnau J

Wed Nov 01 00:00:00 UTC 2023

Inhibition of tiRNA-Gly-GCC ameliorates neointimal formation via CBX3-mediated VSMCs phenotypic switching.

Frontiers in cardiovascular medicine

Rong Z,Li F,Zhang R,Niu S,Di X,Ni L,Liu C

Fri Feb 24 00:00:00 UTC 2023

PCA3 controls chromatin organization and p53 signal activation by regulating LAP2α-lamin A complexes.

Cancer gene therapy

Ito S,Ueda T,Yokoyama A,Fujihara A,Hongo F,Ukimura O

Tue Mar 01 00:00:00 UTC 2022

PCA3 controls chromatin organization and p53 signal activation by regulating LAP2α-lamin A complexes.

Cancer gene therapy

Ito S,Ueda T,Yokoyama A,Fujihara A,Hongo F,Ukimura O

Tue Mar 01 00:00:00 UTC 2022

Autism-associated protein POGZ controls ESCs and ESC neural induction by association with esBAF.

Molecular autism

Sun X,Cheng L,Sun Y

Wed Jun 01 00:00:00 UTC 2022

CBX3 Regulated By YBX1 Promotes Smoking-induced Pancreatic Cancer Progression via Inhibiting SMURF2 Expression.

International journal of biological sciences

Zhang H,Yu H,Ren D,Sun Y,Guo F,Cai H,Zhou C,Zhou Y,Jin X,Wu H

Thu Jun 02 00:00:00 UTC 2022

CBX3 Regulated By YBX1 Promotes Smoking-induced Pancreatic Cancer Progression via Inhibiting SMURF2 Expression.

International journal of biological sciences

Zhang H,Yu H,Ren D,Sun Y,Guo F,Cai H,Zhou C,Zhou Y,Jin X,Wu H

Thu Jun 02 00:00:00 UTC 2022

Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.

Oncogene

Jin X,Zhang B,Zhang H,Yu H

Sat Jan 01 00:00:00 UTC 2022

Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.

Oncogene

Jin X,Zhang B,Zhang H,Yu H

Sat Jan 01 00:00:00 UTC 2022

Smoking-associated upregulation of CBX3 suppresses ARHGAP24 expression to activate Rac1 signaling and promote tumor progression in lung adenocarcinoma.

Oncogene

Jin X,Zhang B,Zhang H,Yu H

Sat Jan 01 00:00:00 UTC 2022

Grp94 Inhibitor HCP1 Inhibits Human Dermal Fibroblast Senescence.

Genes

Cui X,Hao X,Wen J,Zhang S,Zhao B,Miao J

Wed Sep 14 00:00:00 UTC 2022

Grp94 Inhibitor HCP1 Inhibits Human Dermal Fibroblast Senescence.

Genes

Cui X,Hao X,Wen J,Zhang S,Zhao B,Miao J

Wed Sep 14 00:00:00 UTC 2022

Expression and Prognostic Value of Chromobox Family Proteins in Esophageal Cancer.

Genes

Liu J,Shen H,Chen X,Ding Y,Wang H,Xu N,Teng L

Sat Sep 03 00:00:00 UTC 2022

Identification and Validation of Chromobox Family Members as Potential Prognostic Biomarkers and Therapeutic Targets for Human Esophageal Cancer.

Frontiers in genetics

Fang X,Wang J,Chen J,Zhuang M,Huang T,Chen Z,Huang Y,Zheng B,Wang X

Sat Jul 16 00:00:00 UTC 2022

Identification and Validation of Chromobox Family Members as Potential Prognostic Biomarkers and Therapeutic Targets for Human Esophageal Cancer.

Frontiers in genetics

Fang X,Wang J,Chen J,Zhuang M,Huang T,Chen Z,Huang Y,Zheng B,Wang X

Sat Jul 16 00:00:00 UTC 2022

NPM1 promotes cell proliferation by targeting PRDX6 in colorectal cancer.

The international journal of biochemistry & cell biology

Wang D,Li Y,Liu Y,Cheng S,Liu F,Zuo R,Ding C,Shi S,Liu G

Wed Jun 01 00:00:00 UTC 2022

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.

The Journal of experimental medicine

Ma L,Yu L,Jiang BC,Wang J,Guo X,Huang Y,Ren J,Sun N,Gao DS,Ding H,Lu J,Zhou H,Zou L,Gao Y,Wang L,Sun K,Ming Y,Meng Z,Tao YX,Yan M

Mon Dec 06 00:00:00 UTC 2021

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.

The Journal of experimental medicine

Ma L,Yu L,Jiang BC,Wang J,Guo X,Huang Y,Ren J,Sun N,Gao DS,Ding H,Lu J,Zhou H,Zou L,Gao Y,Wang L,Sun K,Ming Y,Meng Z,Tao YX,Yan M

Mon Dec 06 00:00:00 UTC 2021

Prognostic and immune infiltrates for the Chromobox (CBX) protein family in human pancreatic adenocarcinoma.

Journal of gastrointestinal oncology

Li Q,Fu L,Wu D,Wang J

Fri Oct 01 00:00:00 UTC 2021

The LncRNA RP11-279C4.1 Enhances the Malignant Behaviour of Glioma Cells and Glioma Stem-Like Cells by Regulating the miR-1273g-3p/CBX3 Axis.

Molecular neurobiology

Wang F,Zhang L,Luo Y,Zhang Q,Zhang Y,Shao Y,Yuan L

Thu Jul 01 00:00:00 UTC 2021

ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma.

Cancer research

Zhang L,Huo Q,Ge C,Zhao F,Zhou Q,Chen X,Tian H,Chen T,Xie H,Cui Y,Yao M,Li H,Li J

Mon Jun 15 00:00:00 UTC 2020

ZNF143-Mediated H3K9 Trimethylation Upregulates CDC6 by Activating MDIG in Hepatocellular Carcinoma.

Cancer research

Zhang L,Huo Q,Ge C,Zhao F,Zhou Q,Chen X,Tian H,Chen T,Xie H,Cui Y,Yao M,Li H,Li J

Mon Jun 15 00:00:00 UTC 2020

PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.

Journal of virology

He Z,Jing S,Yang T,Chen J,Huang F,Zhang W,Peng Z,Liu B,Ma X,Wu L,Pan T,Zhang X,Li L,Cai W,Tang X,Zhang J,Zhang H

Mon May 04 00:00:00 UTC 2020

CBX3/HP1γ promotes tumor proliferation and predicts poor survival in hepatocellular carcinoma.

Aging

Zhong X,Kan A,Zhang W,Zhou J,Zhang H,Chen J,Tang S

Fri Aug 02 00:00:00 UTC 2019

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Cell

Huang X,Yan J,Zhang M,Wang Y,Chen Y,Fu X,Wei R,Zheng XL,Liu Z,Zhang X,Yang H,Hao B,Shen YY,Su Y,Cong X,Huang M,Tan M,Ding J,Geng M

Thu Sep 20 00:00:00 UTC 2018

Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors.

Cell

Huang X,Yan J,Zhang M,Wang Y,Chen Y,Fu X,Wei R,Zheng XL,Liu Z,Zhang X,Yang H,Hao B,Shen YY,Su Y,Cong X,Huang M,Tan M,Ding J,Geng M

Thu Sep 20 00:00:00 UTC 2018

CBX3 promotes tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma.

Gene

Zhang H,Chen W,Fu X,Su X,Yang A

Tue May 15 00:00:00 UTC 2018

CBX3 promotes tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma.

Gene

Zhang H,Chen W,Fu X,Su X,Yang A

Tue May 15 00:00:00 UTC 2018

CBX3 promotes tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma.

Gene

Zhang H,Chen W,Fu X,Su X,Yang A

Tue May 15 00:00:00 UTC 2018

CBX3 promotes tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma.

Gene

Zhang H,Chen W,Fu X,Su X,Yang A

Tue May 15 00:00:00 UTC 2018

A pH probe inhibits senescence in mesenchymal stem cells.

Stem cell research & therapy

Wang L,Han X,Qu G,Su L,Zhao B,Miao J

Fri Dec 07 00:00:00 UTC 2018

A pH probe inhibits senescence in mesenchymal stem cells.

Stem cell research & therapy

Wang L,Han X,Qu G,Su L,Zhao B,Miao J

Fri Dec 07 00:00:00 UTC 2018

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Nature communications

Yang G,Weng X,Zhao Y,Zhang X,Hu Y,Dai X,Liang P,Wang P,Ma L,Sun X,Hou L,Xu H,Fang M,Li Y,Jenuwein T,Xu Y,Sun A

Fri Mar 31 00:00:00 UTC 2017

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction.

Nature communications

Yang G,Weng X,Zhao Y,Zhang X,Hu Y,Dai X,Liang P,Wang P,Ma L,Sun X,Hou L,Xu H,Fang M,Li Y,Jenuwein T,Xu Y,Sun A

Fri Mar 31 00:00:00 UTC 2017

RNA sequencing identifies novel markers of non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands)

Han SS,Kim WJ,Hong Y,Hong SH,Lee SJ,Ryu DR,Lee W,Cho YH,Lee S,Ryu YJ,Won JY,Rhee H,Park JH,Jang SJ,Lee JS,Choi CM,Lee JC,Lee SD,Oh YM

Sun Jun 01 00:00:00 UTC 2014

RNA sequencing identifies novel markers of non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands)

Han SS,Kim WJ,Hong Y,Hong SH,Lee SJ,Ryu DR,Lee W,Cho YH,Lee S,Ryu YJ,Won JY,Rhee H,Park JH,Jang SJ,Lee JS,Choi CM,Lee JC,Lee SD,Oh YM

Sun Jun 01 00:00:00 UTC 2014

Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins.

The Journal of cell biology