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CBX7 Polyclonal Antibody

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CBX7 Antibody (26278-1-AP) in WB

mouse liver tissue were subjected to SDS PAGE followed by western blot with (Product # 26278-1-AP) (CBX7 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

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Product Details

26278-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CBX7 Fusion Protein Ag24588

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.29 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Target Information

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Downregulation of CBX7 induced by EZH2 upregulates FGFR3 expression to reduce sensitivity to cisplatin in bladder cancer.

British journal of cancer

Ren J,Yu H,Li W,Jin X,Yan B

Sun Jan 01 00:00:00 UTC 2023

Downregulation of CBX7 induced by EZH2 upregulates FGFR3 expression to reduce sensitivity to cisplatin in bladder cancer.

British journal of cancer

Ren J,Yu H,Li W,Jin X,Yan B

Sun Jan 01 00:00:00 UTC 2023

Downregulation of CBX7 induced by EZH2 upregulates FGFR3 expression to reduce sensitivity to cisplatin in bladder cancer.

British journal of cancer

Ren J,Yu H,Li W,Jin X,Yan B

Sun Jan 01 00:00:00 UTC 2023

CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.

Tissue engineering and regenerative medicine

Wu Y,Li B,Yu D,Zhou Z,Shen M,Jiang F

Thu Jun 01 00:00:00 UTC 2023

Loss of CBX2 causes genomic instability and Wnt activation in high grade serous ovarian carcinoma cells.

Molecular carcinogenesis

Ma Y,Liu L,Wei Z,Zhu M,Huang L,Wang S,Yi X,Ying F,Zhao S,Cai J,Wang Z,Sun S

Sat Apr 01 00:00:00 UTC 2023

Comprehensive analysis reveals the value of the expression of chromobox family members for bladder urothelial carcinoma prognosis.

Oncology letters

Meng X,Cao R,Liu X,Fu B,Luo L,Jiang M,Wang K,Liu Y,Zhu Q,Yang C,Zhou L

Sat Apr 01 00:00:00 UTC 2023

Circ_0006790 carried by bone marrow mesenchymal stem cell-derived exosomes regulates S100A11 DNA methylation through binding to CBX7 in pancreatic ductal adenocarcinoma.

American journal of cancer research

Gao G,Wang L,Li C

Sat Jul 16 00:00:00 UTC 2022

The RNF26/CBX7 axis modulates the TNF pathway to promote cell proliferation and regulate sensitivity to TKIs in ccRCC.

International journal of biological sciences

Liu W,Wang H,Jian C,Li W,Ye K,Ren J,Zhu L,Wang Y,Jin X,Yi L

Fri Apr 15 00:00:00 UTC 2022

The RNF26/CBX7 axis modulates the TNF pathway to promote cell proliferation and regulate sensitivity to TKIs in ccRCC.

International journal of biological sciences

Liu W,Wang H,Jian C,Li W,Ye K,Ren J,Zhu L,Wang Y,Jin X,Yi L

Fri Apr 15 00:00:00 UTC 2022

CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer.

Biochemical and biophysical research communications

Ren W,Ren J,Zhang N,Liu X,Deng Y,Jiang Y,Yan B,Xiao X,Yu H

Tue Jul 12 00:00:00 UTC 2022

CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer.

Biochemical and biophysical research communications

Ren W,Ren J,Zhang N,Liu X,Deng Y,Jiang Y,Yan B,Xiao X,Yu H

Tue Jul 12 00:00:00 UTC 2022

CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer.

Biochemical and biophysical research communications

Ren W,Ren J,Zhang N,Liu X,Deng Y,Jiang Y,Yan B,Xiao X,Yu H

Tue Jul 12 00:00:00 UTC 2022

CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer.

Biochemical and biophysical research communications

Ren W,Ren J,Zhang N,Liu X,Deng Y,Jiang Y,Yan B,Xiao X,Yu H

Tue Jul 12 00:00:00 UTC 2022

Identification and Validation of Chromobox Family Members as Potential Prognostic Biomarkers and Therapeutic Targets for Human Esophageal Cancer.

Frontiers in genetics

Fang X,Wang J,Chen J,Zhuang M,Huang T,Chen Z,Huang Y,Zheng B,Wang X

Sat Jul 16 00:00:00 UTC 2022

Identification and Validation of Chromobox Family Members as Potential Prognostic Biomarkers and Therapeutic Targets for Human Esophageal Cancer.

Frontiers in genetics

Fang X,Wang J,Chen J,Zhuang M,Huang T,Chen Z,Huang Y,Zheng B,Wang X

Sat Jul 16 00:00:00 UTC 2022

CBX7, a Potential Prognostic Biomarker in Lung Adenocarcinoma.

OncoTargets and therapy

Yang Y,Hu Z,Sun H,Yu Q,Yang L,Yin F,Sun Y,Pu L,Zhu X,Li S,Chen X,Zhao Y

Fri Apr 29 00:00:00 UTC 2022

Bioinformatics

Protein Aliases: chromobox homolog 7; Chromobox protein homolog 7

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Gene Aliases: 1600014J01Rik; AI851678; CBX7; D15Ertd417e

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UniProt ID: (Human) O95931, (Mouse) Q8VDS3

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Entrez Gene ID: (Human) 23492, (Mouse) 52609

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Function(s)

chromatin binding single-stranded RNA binding protein binding methylated histone binding RNA binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter transcription, DNA-templated covalent chromatin modification response to drug sebaceous gland development regulation of transcription, DNA-templated chromatin modification

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CBX7 Polyclonal Antibody

CBX7 Antibody (26278-1-AP) in WB

Product Details

26278-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Target Information

Bioinformatics

Performance Guarantee

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