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Invitrogen
CCBE1 Polyclonal Antibody
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Product Details
PA5-37245
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to residues in human CCBE1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2553979
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 44 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The gene encoding CCBE1 (Collagen and calcium-binding EGF domain-containing protein 1) is located on chromosome 18 in a region that is frequently found to be deleted in breast and prostate cancers. CCBE1 is a 406 amino acid secreted protein that contains two collagen-like domains and one calcium-binding epidermal growth factor (EGF-like) domain. In general, EGF-like domains include six cysteine residues that are usually involved in disulfide bonds. Calcium-binding EGF-like domains are subject to amino acid substitutions that disrupt their structure or calcium affinity, therefore altering protein function. Downregulation of the gene encoding CCBE1 is observed with high frequency in breast cancer, suggesting that loss of CCBE1 results in changes in cell adhesion and mobility due to its characterization as an extracellular protein. There are three named isoforms of CCBE1 which are produced as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: collagen and calcium binding EGF domains 1; Collagen and calcium-binding EGF domain-containing protein 1; FLJ30681; Full of fluid protein homolog; MGC50861
Gene Aliases: 4933426F18Rik; 9430093N24Rik; CCBE1; HKLLS1; KIAA1983; mKIAA1983; RGD1307670; UNQ1921/PRO4395
UniProt ID: (Human) Q6UXH8, (Mouse) Q3MI99
Entrez Gene ID: (Human) 147372, (Mouse) 320924, (Rat) 361341
lymphangiogenesis
sprouting angiogenesis
positive regulation of vascular endothelial growth factor production
positive regulation of endothelial cell migration
positive regulation of protein processing
positive regulation of angiogenesis
venous blood vessel morphogenesis
positive regulation of vascular endothelial growth factor signaling pathway
positive regulation of lymphangiogenesis
angiogenesis
multicellular organism development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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