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Invitrogen
CCDC151 Polyclonal Antibody
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Product Details
PA5-62991
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CCDC151. Recombinant protein control fragment (Product #RP-104275).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2639405
Product Specific Information
Immunogen sequence: LLDLLKGDEK VVQAVIREWK WEKPYLKNRT GQALEHLDHR LREKVKQQNA LRHQVVLRQR RLEELQLQHS LRLLEMAEAQ NRHTEVAKTM RNLE
Highest antigen sequence identity to the following orthologs: Mouse - 73%, Rat - 76%.
Target Information
CCDC151 (Coiled-Coil Domain-Containing 151) is a gene located on chromosome 19p13.2 that encodes a protein essential for the assembly and function of motile cilia. The protein is highly conserved across species with motile cilia and is the vertebrate ortholog of the Chlamydomonas ODA10 gene. CCDC151 is crucial for the assembly and docking of outer dynein arms (ODAs) on the axoneme of cilia, which are necessary for ciliary beating and motility. Mutations in CCDC151 have been linked to primary ciliary dyskinesia (PCD), a genetic disorder characterized by chronic respiratory infections, abnormal organ positioning (situs inversus), and infertility due to defective ciliary movement. Studies in zebrafish and mouse models have demonstrated that mutations in CCDC151 lead to a spectrum of situs defects and complex heart abnormalities. These findings underscore the pivotal role of CCDC151 in ciliary function and its implications in human health and disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Coiled-coil domain-containing protein 151; Outer dynein arm-docking complex subunit 3
Gene Aliases: CCDC151; CILD30; ODAD3
UniProt ID: (Human) A5D8V7
Entrez Gene ID: (Human) 115948
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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