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OriGene
CCDC22 Monoclonal Antibody (OTI5C1), TrueMAB™
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CCDC22 Antibody (CF811112) in IHC (P)
Immunohistochemical staining of paraffin-embedded human endometrium tissue within the normal limits using anti-CCDC22 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA811112)(1:500).
Product Details
CF811112
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5C1
Immunogen
Full length human recombinant protein of human CCDC22 produced in E.coli.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 8% trehalose
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
Target Information
CCDC22 is a recently identified coiled-coil domain-containing protein that has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. In rat, CCDC22 has been observed to localize in multiple regions of the brain, including the prefrontal and somatosensory cortex, dentate gyrus and thalamus, and in the ipsilateral motor neurons of the spinal cord after sciatic nerve transection suggesting that it may play a role in neuronal injury response. The human CCDC22 gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability (XLID).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ccdc22 {ECO:0000250|UniProtKB:O60826}; Coiled-coil domain-containing protein 22; coiled-coil domain-containing protein 22 {ECO:0000250|UniProtKB:O60826}
Gene Aliases: AI481216; CCDC22; CXorf37; DXImx40e; JM1; Ppp1r3f; RGD1560910; RTSC2; Sfc22
UniProt ID: (Human) O60826, (Mouse) Q9JIG7, (Rat) P86182
Entrez Gene ID: (Human) 28952, (Mouse) 54638, (Rat) 317381
cellular copper ion homeostasis
Golgi to plasma membrane transport
cytoplasmic sequestering of NF-kappaB
protein transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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