Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Product Details
CCK4-401AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Purified Protein tyrosine kinase 7 protein was emulsified in complete adjuvant and used to immunize the rabbits.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
CCK4 may function as a cell adhesion molecule. Although it belongs to the insulin receptor subfamily of the Tyr protein kinases, it likely lacks the catalytic activity of a tyrosine kinase. It may be connected to the pathophysiology of colon carcinomas and/or may represent a tumor progression marker. This Type I membrane protein is highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes, but weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle, and not in colon. It is also expressed in erythroleukemia cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: CCK-4; Colon carcinoma kinase 4; Inactive tyrosine-protein kinase 7; Protein chuzhoi; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; PTK7 protein tyrosine kinase 7; receptor tyrosine kinase-like protein; serum response factor; Tyrosine-protein kinase-like 7
Gene Aliases: 8430404F20Rik; CCK-4; CCK4; chz; mPTK7/CCK4; PTK7; Srf
UniProt ID: (Human) Q13308, (Mouse) Q8BKG3
Entrez Gene ID: (Human) 5754, (Rat) 301242, (Mouse) 71461
protein kinase activity
protein binding
ATP binding
coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity, transferring phosphorus-containing groups
establishment of planar polarity
neural tube closure
axis elongation
protein phosphorylation
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine phosphorylation
actin cytoskeleton reorganization
wound healing
establishment of epithelial cell apical/basal polarity
convergent extension
canonical Wnt signaling pathway
lung-associated mesenchyme development
cellular response to retinoic acid
cochlea morphogenesis
planar cell polarity pathway involved in neural tube closure
cell adhesion
Wnt signaling pathway
ventricular septum development
signal transduction
coronary vasculature development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support