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Invitrogen
CCL5 (RANTES) Monoclonal Antibody (R6G9), eBioscience™
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-WB-20170216130641.jpg?time=20250104 "CCL5 (RANTES) Antibody in Western Blot (WB)")
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-WB-20170216130641.jpg?time=20250104?time=20250104 "CCL5 (RANTES) Antibody (14-7085-37) in WB")
Product Details
14-7085-37
Applications
Tested Dilution
Publications
Product Specifications
Published species
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
R6G9
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Storage conditions
4°C
Shipping conditions
Wet ice
RRID
AB_2865263
Product Specific Information
Description: RANTES (Regulated on Activation, Normal T Expressed and Secreted) is an 8kD member of the C-C family of chemkines (CCL5). It is a proinflammatory chemoattractant for several cell types including CD4+ T cells, monocytes and eosinophils. In contrast to other members of the chemokine superfamily, RANTES has been observed to be downregulated upon activation in T cells. In other secreting cells, upregulation is observed in response to activation.
Applications Reported: This R6G9 antibody has been reported for use in immunoblotting (WB).
Applications Tested: This R6G9 antibody has been tested by immunoblot on lysates of LPS-activated Raw 264.7 cells. This can be used at less than or equal to 2 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Purity: Greater than 90%, as determined by SDS-PAGE.
Aggregation: Less than 10%, as determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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