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Proteintech
CCM2 Polyclonal Antibody
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Product Details
26270-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CCM2 Fusion Protein Ag24233 (88-298 aa encoded by BC004903)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ILHFIDNAK RAHQLPGHLT QEHDAVLSLS AYNVKLAWRD GEDIILRVPI HDIAAVSYVR DDAAHLVVLK TAQDPGISPS QSLCAESSRG LSAGSLSESA VGPVEACCLV ILAAESKVAA EELCCLLGQV FQVVYTESTI DFLDRAIFDG ASTPTHHLSL HSDDSSTKVD IKETYEVEAS TFCFPESVDV GGASPHSKTI SESELSASAT EL (88-298 aa encoded by BC004903)
Target Information
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cerebral cavernous malformation 2; Cerebral cavernous malformations 2 protein; Malcavernin; MGC4067; MGC4607; MGC74868; Oncostatin; OncostatinM; osmosensing scaffold for MEKK3
Gene Aliases: C7orf22; CCM2; OSM; PP10187
UniProt ID: (Human) Q9BSQ5
Entrez Gene ID: (Human) 83605
vasculogenesis
in utero embryonic development
endothelial cell development
integrin-mediated signaling pathway
multicellular organism growth
cell-cell junction organization
inner ear development
venous blood vessel morphogenesis
stress-activated MAPK cascade
pericardium development
blood vessel endothelial cell differentiation
endothelial tube morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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