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Product Details
13138-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CCNL1 Fusion Protein Ag3731 (227-526 aa encoded by BC007081)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: YMNDSLRTN VFVRFQPETI ACACIYLAAR ALQIPLPTRP HWFLLFGTTE EEIQEICIET LRLYTRKKPN YELLEKEVEK RKVALQEAKL KAKGLNPDGT PALSTLGGFS PASKPSSPRE VKAEEKSPIS INVKTVKKEP EDRQQASKSP YNGVRKDSKR SRNSRSASRS RSRTRSRSRS HTPRRHYNNR RSRSGTYSSR SRSRSRSHSE SPRRHHNHGS PHLKAKHTRD DLKSSNRHGH KRKKSRSRSQ SKSRDHSDAA KKHRHERGHH RDRRERSRSF ERSHKSKHHG GSRSGHGRHR R (227-526 aa encoded by BC007081)
Target Information
FUS/TLS was originally described as fused in Sarcoma is actually related to a number of different cellular processes and correlated to several diseases. FUS binds DNA as a single or double strand, and acts as a site for transcription factors to recognize. Since FUS is well-documented to be involved in liposarcoma, lipoma and leukaemia, it is believed that when its normal housekeeping functions related to transcription are disrupted, normal cells become cancerous. Interestingly, FUS is also associated with the fatal neuron disorder amyotrophic lateral sclerosis; interruption of its normal RNA-binding functions leads to incorrect cellular localization and leads to pathologies of the neuron. Thus, FUS regulation of cellular functions is a critical component of maintenance of healthy cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cyclin Ania-6a; cyclin L ania-6a; cyclin L gamma; Cyclin-L; Cyclin-L1
Gene Aliases: 2610030E23Rik; Ania-6a; ANIA6A; AU018493; BM-001; Ccn1; Ccnl; CCNL1; PRO1073; UNQ530/PRO1073
UniProt ID: (Human) Q9UK58, (Mouse) Q52KE7, (Rat) Q9R1Q2
Entrez Gene ID: (Human) 57018, (Mouse) 56706, (Rat) 114121
regulation of cyclin-dependent protein serine/threonine kinase activity
transcription, DNA-templated
regulation of transcription, DNA-templated
RNA processing
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of transcription from RNA polymerase II promoter
positive regulation of phosphorylation of RNA polymerase II C-terminal domain
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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