Proteintech

CCPG1 Polyclonal Antibody

CCPG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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CCPG1 Antibody (13861-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human stomach cancer tissue slide using (Product # 13861-1-AP) (CCPG1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

CCPG1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13861-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 12 publications 12 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CCPG1 Fusion Protein Ag4841 (264-613 aa encoded by BC034914)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LHGKSDSPN VYTEKKEIAI LRERLTELEL KLTFEQQRSD LWERLYVEAK DQNGKQGTDG KKKGGRGSHR AKNKSKETFL GSVKETFDAM KNSTKEFVRH HKEKIKQAKE AVKENLKKFS DSVKSTFRHF KDTTKNIFDE KGNKRFGATK EAAEKPRTVF SDYLHPQYKA PTENHHNRGP TMQNDGRKEK PVHFKEFRKN TNSKKCSPGH DCRENSHSFR EACSGVFDCA QQESMSLFNI VVNPIRMDEF RQIIQRYMLK ELDTFCHWNE LDQFINKFFL NGVFIHDQKL FTDFVNDVKD YLRNMKEYEV DNDGVFEKLD EYIYRHFFGH TFSPPYGPRS VYIKPCHYSS L (264-613 aa encoded by BC034914)

Target Information

Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42. May be involved in cell cycle regulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The Activation of Reticulophagy by ER Stress through the ATF4-MAP1LC3A-CCPG1 Pathway in Ovarian Granulosa Cells Is Linked to Apoptosis and Necroptosis.

International journal of molecular sciences

Li H,Jing Y,Qu X,Yang J,Pan P,Liu X,Gao H,Pei X,Zhang C,Yang Y

Wed Feb 01 00:00:00 UTC 2023

CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy.

Molecular biology of the cell

Ishii S,Chino H,Ode KL,Kurikawa Y,Ueda HR,Matsuura A,Mizushima N,Itakura E

Sat Apr 01 00:00:00 UTC 2023

Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression.

Journal of pineal research

Yao M,Pu PM,Li ZY,Zhu K,Zhou LY,Sun YL,Dai YX,Cui XJ,Wang YJ

Mon May 01 00:00:00 UTC 2023

Lysosome docking to WIPI1 rings and ER-connected phagophores occurs during DNAJB12- and GABARAP-dependent selective autophagy of misfolded P23H-rhodopsin.

Molecular biology of the cell

Kennedy A,Ren HY,Madden VJ,Cyr DM

Mon Aug 01 00:00:00 UTC 2022

Piperine alleviates acute pancreatitis: A possible role for FAM134B and CCPG1 dependent ER-phagy.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Huang W,Zhang J,Jin W,Yang J,Yu G,Shi H,Shi K

Sat Oct 01 00:00:00 UTC 2022

Piperine alleviates acute pancreatitis: A possible role for FAM134B and CCPG1 dependent ER-phagy.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Huang W,Zhang J,Jin W,Yang J,Yu G,Shi H,Shi K

Sat Oct 01 00:00:00 UTC 2022

ATF4 links ER stress with reticulophagy in glioblastoma cells.

Autophagy

Zielke S,Kardo S,Zein L,Mari M,Covarrubias-Pinto A,Kinzler MN,Meyer N,Stolz A,Fulda S,Reggiori F,Kögel D,van Wijk S

Wed Sep 01 00:00:00 UTC 2021

Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins.

Biology direct

Herrera-Cruz MS,Yap MC,Tahbaz N,Phillips K,Thomas L,Thomas G,Simmen T

Sun Nov 07 00:00:00 UTC 2021

Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.

Molecular cell

Zellner S,Schifferer M,Behrends C

Thu Mar 18 00:00:00 UTC 2021

TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.

Molecular cell

An H,Ordureau A,Paulo JA,Shoemaker CJ,Denic V,Harper JW

Thu Jun 06 00:00:00 UTC 2019

Intrinsically Disordered Protein TEX264 Mediates ER-phagy.

Molecular cell

Chino H,Hatta T,Natsume T,Mizushima N

Thu Jun 06 00:00:00 UTC 2019

Cells Deploy a Two-Pronged Strategy to Rectify Misfolded Proinsulin Aggregates.

Molecular cell

Cunningham CN,Williams JM,Knupp J,Arunagiri A,Arvan P,Tsai B

Thu Aug 08 00:00:00 UTC 2019

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis.

Developmental cell

Smith MD,Harley ME,Kemp AJ,Wills J,Lee M,Arends M,von Kriegsheim A,Behrends C,Wilkinson S

Mon Jan 22 00:00:00 UTC 2018

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis.

Developmental cell

Smith MD,Harley ME,Kemp AJ,Wills J,Lee M,Arends M,von Kriegsheim A,Behrends C,Wilkinson S

Mon Jan 22 00:00:00 UTC 2018

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis.

Developmental cell

Smith MD,Harley ME,Kemp AJ,Wills J,Lee M,Arends M,von Kriegsheim A,Behrends C,Wilkinson S

Mon Jan 22 00:00:00 UTC 2018

CCPG1 Is a Non-canonical Autophagy Cargo Receptor Essential for ER-Phagy and Pancreatic ER Proteostasis.

Developmental cell

Smith MD,Harley ME,Kemp AJ,Wills J,Lee M,Arends M,von Kriegsheim A,Behrends C,Wilkinson S

Mon Jan 22 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: cell cycle progression 8 protein; Cell cycle progression protein 1; Cell cycle progression restoration protein 8

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Gene Aliases: 1700030B06Rik; 1810073J13Rik; 9430028F23Rik; AI426686; AI875170; CCP8; CCPG1; CPR8; D9Ertd392e; KIAA1254

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UniProt ID: (Human) Q9ULG6, (Mouse) Q640L3

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Entrez Gene ID: (Human) 9236, (Rat) 363098, (Mouse) 72278

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Function(s)

molecular_function protein binding

Process(es)

positive regulation of cell proliferation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter regulation of Rho guanyl-nucleotide exchange factor activity cell cycle

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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CCPG1 Polyclonal Antibody

CCPG1 Antibody (13861-1-AP) in IHC (P)

Product Details

13861-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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