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Product Details
CCR1-101-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 1-50 on mouse CCR1 protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines. One of the CCR receptors, CCR1, is expressed on neutrophils, monocytes, lymphocytes, and eosinophils and binds the leukocyte chemoattractant and hemopoiesis regulator macrophage-inflammatory protein (MIP-1 ), eotaxin, as well as several other related chemokines. Mice lacking the chemokine receptor CCR1 have defects in neutrophil trafficking and proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CD191; chemokine (C-C) receptor 1; Macrophage inflammatory protein 1-alpha receptor; macrophage inflammatory protein-1 alpha receptor; MIP-1 alpha R; MIP-1 alphaR; MIP-1alpha-R; RANTES-R
Gene Aliases: Ccr1; Cmkbr1; Mip-1a-R
UniProt ID: (Mouse) P51675
Entrez Gene ID: (Mouse) 12768, (Rat) 57301
calcium ion transport
cellular calcium ion homeostasis
exocytosis
chemotaxis
inflammatory response
immune response
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
metabolic process
negative regulation of gene expression
myeloid cell differentiation
positive regulation of cell migration
negative regulation of bone mineralization
leukocyte chemotaxis
positive regulation of osteoclast differentiation
negative regulation of innate immune response
positive regulation of calcium ion transport
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
positive regulation of monocyte chemotaxis
cerebellum development
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