Invitrogen

CCR2 Polyclonal Antibody, Biotin

View all (32) CCR2 (CD192) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-23038

Applications
Tested Dilution
Publications

Western Blot (WB)

1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

Assay-Dependent
-

Immunocytochemistry (ICC/IF)

1:50
-

Flow Cytometry (Flow)

1:50
-
Product Specifications

Species Reactivity

Bovine, Cat, Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide made to an N-terminal portion of the human CCR2 protein (within residues 20-100).
View immunogen

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.99 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_11155772

Target Information

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; Cc-ckr2; CCR-2; CD192; CD192 antigen; chemokine (C-C motif) receptor 2; chemokine receptor CCR2; hCG_14621; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

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Gene Aliases: BOS_21181; CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R

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UniProt ID: (Human) P41597, (Rat) O55193

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Entrez Gene ID: (Bovine) 539002, (Cat) 100049057, (Human) 729230, (Rat) 60463

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Function(s)
chemokine receptor activity C-C chemokine receptor activity protein kinase binding CCR2 chemokine receptor binding protein homodimerization activity chemokine (C-C motif) ligand 5 binding cytokine binding chemokine binding C-C chemokine binding chemokine (C-C motif) ligand 2 binding chemokine (C-C motif) ligand 12 binding chemokine (C-C motif) ligand 7 binding
Process(es)
response to hypoxia blood vessel remodeling inflammatory response to antigenic stimulus monocyte chemotaxis positive regulation of T-helper 1 type immune response negative regulation of type 2 immune response cellular calcium ion homeostasis inflammatory response immune response humoral immune response cellular defense response G-protein coupled receptor signaling pathway regulation of vascular endothelial growth factor production positive regulation of T cell chemotaxis negative regulation of angiogenesis cytokine-mediated signaling pathway sensory perception of pain cellular homeostasis hemopoiesis regulation of cell migration positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of tumor necrosis factor production T-helper 17 cell chemotaxis positive regulation of tumor necrosis factor biosynthetic process negative regulation of eosinophil degranulation positive regulation of MAPK cascade positive regulation of alpha-beta T cell proliferation positive regulation of inflammatory response positive regulation of T cell activation response to hyperoxia chemokine-mediated signaling pathway positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages positive regulation of monocyte extravasation positive regulation of CD8-positive, alpha-beta T cell extravasation positive regulation of astrocyte chemotaxis positive regulation of hematopoietic stem cell migration dendritic cell chemotaxis chemotaxis negative regulation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration JAK-STAT cascade aging response to wounding response to ionizing radiation positive regulation of gene expression negative regulation of cell migration negative regulation of axon extension forebrain development positive regulation of fever generation response to lipopolysaccharide positive regulation of interleukin-6 production defense response to bacterium fat cell differentiation positive regulation of neuron differentiation positive regulation of interleukin-1 beta secretion positive regulation of apoptotic process by virus neuron death positive regulation of cell migration involved in sprouting angiogenesis negative regulation of neural precursor cell proliferation
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