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Product Details
H00001231-M01
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgM, kappa
Class
Monoclonal
Type
Antibody
Clone
4D12
Immunogen
CCR2 (NP_000639, 1 a.a. approximately 42 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MLSTSRSRFI RNTNESGEEV TTFFDYDYGA PCHKFDVKQI GA
Target Information
CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C chemokine receptor type 2; C-C CKR-2; Cc-ckr2; CD192; CD192 antigen; chemokine (C-C motif) receptor 2; hCG_14621; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
Gene Aliases: CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
UniProt ID: (Human) P41597
Entrez Gene ID: (Human) 729230
blood vessel remodeling
dendritic cell chemotaxis
inflammatory response to antigenic stimulus
positive regulation of T-helper 1 type immune response
negative regulation of type 2 immune response
cellular calcium ion homeostasis
chemotaxis
inflammatory response
immune response
cellular defense response
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
aging
response to wounding
response to ionizing radiation
regulation of vascular endothelial growth factor production
positive regulation of gene expression
positive regulation of T cell chemotaxis
negative regulation of angiogenesis
cytokine-mediated signaling pathway
cellular homeostasis
negative regulation of cell migration
negative regulation of axon extension
forebrain development
positive regulation of fever generation
response to lipopolysaccharide
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-6 production
T-helper 17 cell chemotaxis
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
negative regulation of eosinophil degranulation
fat cell differentiation
positive regulation of neuron differentiation
positive regulation of alpha-beta T cell proliferation
positive regulation of interleukin-1 beta secretion
positive regulation of inflammatory response
positive regulation of T cell activation
positive regulation of apoptotic process by virus
chemokine-mediated signaling pathway
neuron death
positive regulation of monocyte chemotaxis
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of immune complex clearance by monocytes and macrophages
negative regulation of neural precursor cell proliferation
positive regulation of monocyte extravasation
positive regulation of CD8-positive, alpha-beta T cell extravasation
positive regulation of astrocyte chemotaxis
positive regulation of hematopoietic stem cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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