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Product Details
MA1-20282
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
HEK/1/85a
Immunogen
CHO cells transfected with human CCR5.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.1 mg/mL
Purification
Protein G
Storage buffer
PBS with 1% BSA
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_558101
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells. CCR5 is required for the infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1. CCR5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells. The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites. CCR5 messenger RNA is expressed in lymphoid organs and monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-C chemokine receptor type 5; C-C CKR-5; C-C motif chemokine receptor 5 A159A; CC-CKR-5; CCR-5; CD195; CD195 antigen; chemokine (C-C motif) receptor 5; chemokine (C-C) receptor 5; chemokine receptor CCR5; CHEMR13; HIV-1 fusion coreceptor; MIP-1 alpha receptor
Gene Aliases: AM4-7; CC-CKR-5; CCCKR5; CCR-5; CCR5; CD195; CKR-5; CKR5; CMKBR5; IDDM22
UniProt ID: (Human) P51681, (Mouse) P51682
Entrez Gene ID: (Human) 1234, (Mouse) 12774
virus receptor activity
actin binding
phosphatidylinositol phospholipase C activity
chemokine receptor activity
protein binding
coreceptor activity
C-C chemokine receptor activity
C-C chemokine binding
chemokine (C-C motif) ligand 5 binding
glycoprotein binding
signal transducer activity
G-protein coupled receptor activity
protein kinase binding
MAPK cascade
dendritic cell chemotaxis
calcium ion transport
chemotaxis
inflammatory response
immune response
cellular defense response
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
fusion of virus membrane with host plasma membrane
calcium-mediated signaling
signaling
entry into host cell
chemokine-mediated signaling pathway
response to cholesterol
cellular response to lipopolysaccharide
defense response
signal transduction
positive regulation of gene expression
positive regulation of cell-cell adhesion
negative regulation of cell migration
negative regulation of axon extension
positive regulation of fever generation
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of neuron differentiation
positive regulation of interleukin-1 beta secretion
positive regulation of inflammatory response
positive regulation of apoptotic process by virus
neuron death
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of macrophage apoptotic process
negative regulation of neural precursor cell proliferation
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